De Grandi P, Nguyen The H, Suppan P, Kunz B
J Gynecol Obstet Biol Reprod (Paris). 1979 Jul-Aug;8(5):455-62.
Prostaglandin F2-alpha was administered extra-amniotic as a gel through the cervix uteri to 100 patients in the 2nd trimester of pregnancy: 82 for termination of pregnancy, 17 for intrauterine death, and 1 for a hydatiform mole. The success rate was 96 p. 100. Mean duration of induction was 17 hrs 06 min., cervical priming lowered this duration to 11 hrs 40 min. (p less than 0.01). Extradural analgesia provided satisfactory pain relief and allowed a dilatation and curettage to be performed without recoure to a general anaesthetic. The technique described showed a lower incidence of side-effects than other modes of administration of PG F2-alpha, and proved to be effective, reliable, and acceptable to patients.
将前列腺素F2-α制成凝胶,通过子宫颈在羊膜外给予100例妊娠中期患者:82例用于终止妊娠,17例用于处理宫内死胎,1例用于处理葡萄胎。成功率为96%。平均引产时间为17小时06分钟,宫颈预处理后该时间降至11小时40分钟(P<0.01)。硬膜外镇痛提供了满意的疼痛缓解,使得刮宫术无需全身麻醉即可进行。所描述的技术与前列腺素F2-α的其他给药方式相比,副作用发生率更低,且被证明有效、可靠且患者可接受。