Wilson C B, Remington J S
J Infect Dis. 1979 Dec;140(6):890-5. doi: 10.1093/infdis/140.6.890.
Previous reports on the ability of Toxoplasma gondii to multiply within human mononuclear phagocytes have supported the concept that the phagocytes may protect Toxoplasma from antibody and act as a transport mechanism for dissemination of the organism throughout the body. However, after phagocytosis of viable Toxoplasma, greater than 80% of freshly isolated human peripheral blood monocytes and 50% of polymorphonuclear leukocytes rapidly destroyed these intracellular organisms. Virtually no replication of Toxoplasma occurred within these cells, as determined by microscopic examination and by uptake of [3H]uracil. These results suggested that circulating phagocytes from humans restrict rather than facilitate the initial dissemination of Toxoplasma.
先前关于刚地弓形虫在人类单核吞噬细胞内增殖能力的报告支持了这样一种观点，即吞噬细胞可能保护弓形虫免受抗体作用，并作为一种将该生物体传播至全身的转运机制。然而，在吞噬活的弓形虫后，超过80%的新鲜分离的人外周血单核细胞和50%的多形核白细胞迅速破坏这些细胞内的生物体。通过显微镜检查和[3H]尿嘧啶摄取测定，实际上弓形虫在这些细胞内没有发生增殖。这些结果表明，来自人类的循环吞噬细胞限制而非促进弓形虫的初始传播。
