对海拉细胞在细胞生长周期不同阶段的不均一核RNA的比较。
A comparison of the heterogeneous nuclear RNA of HeLa cells in different periods of the cell growth cycle.
作者信息
Pagoulatos G N, Darnell J E
出版信息
J Cell Biol. 1970 Mar;44(3):476-83. doi: 10.1083/jcb.44.3.476.
Abstract
HeLa cells synthesize heterogeneous nuclear RNA (HnRNA) in the G(1), S, and G(2) portions of the cell cycle. HnRNA prepared from these various periods was compared by RNA-DNA hybridization experiments. The results indicated that some of the HnRNA molecules were equivalent at all times in the cell cycle, but limitations in the sensitivity of the hydridization reactions, as well as in the spectrum of hybridizing molecules, restrict the conclusions that can be drawn from these comparisons.
摘要
海拉细胞在细胞周期的G1期、S期和G2期合成不均一核RNA（HnRNA）。通过RNA-DNA杂交实验对从这些不同时期制备的HnRNA进行了比较。结果表明，某些HnRNA分子在细胞周期的所有时间都是等同的，但是杂交反应敏感性以及杂交分子谱方面的局限性，限制了从这些比较中得出的结论。
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