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A comparison between heterogeneous nuclear RNA and polysomal messenger RNA in HeLa cells by RNA-DNA hybridization.通过RNA-DNA杂交对海拉细胞中的不均一核RNA和多聚核糖体信使RNA进行比较。
J Cell Biol. 1970 Mar;44(3):467-75. doi: 10.1083/jcb.44.3.467.
2
A comparison of the heterogeneous nuclear RNA of HeLa cells in different periods of the cell growth cycle.对海拉细胞在细胞生长周期不同阶段的不均一核RNA的比较。
J Cell Biol. 1970 Mar;44(3):476-83. doi: 10.1083/jcb.44.3.476.
3
Double-stranded regions in heterogeneous nuclear RNA from Hela cells.来自海拉细胞的不均一核RNA中的双链区域。
Proc Natl Acad Sci U S A. 1972 Sep;69(9):2537-41. doi: 10.1073/pnas.69.9.2537.
4
Identification of a small subfraction of hnRNA with the characteristics of a precursor to mRNA.鉴定出一小部分具有mRNA前体特征的核内不均一RNA。
Cell. 1974 Aug;2(4):253-8. doi: 10.1016/0092-8674(74)90019-1.
5
Production of viral mRNA in adenovirus- transformed cells by the post- transcriptional processing of heterogeneous nuclear RNA containing viral and cell sequences.在腺病毒转化细胞中，通过对含有病毒和细胞序列的异质性核RNA进行转录后加工来产生病毒mRNA。
J Virol. 1973 Jun;11(6):953-60. doi: 10.1128/JVI.11.6.953-960.1973.
6
Repetitious and unique sequences in the heterogeneous nuclear and cytoplasmic messenger RNA of mammalian and insect cells.哺乳动物和昆虫细胞的不均一核信使核糖核酸及细胞质信使核糖核酸中的重复序列和独特序列。
Cell. 1974 Sep;3(1):23-30. doi: 10.1016/0092-8674(74)90033-6.
7
Comparison of nucleotide sequences in HeLa cell mRNA and hnRNA.HeLa细胞mRNA与hnRNA中核苷酸序列的比较。
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Methyl labeling of HeLa cell hnRNA: a comparison with mRNA.HeLa细胞核内不均一RNA的甲基化标记：与信使RNA的比较。
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引用本文的文献

1
Transport of viral RNA in kb cells infected with adenovirus type 2.腺病毒 2 型感染的 kb 细胞中病毒 RNA 的转运。
J Cell Biol. 1971 May 1;49(2):438-49. doi: 10.1083/jcb.49.2.438.
2
Transcription of Ribosomal and Messenger RNAs in Early Wheat Embryo Germination.核糖体和信使 RNA 在小麦胚胎萌发早期的转录。
Plant Physiol. 1975 Oct;56(4):502-7. doi: 10.1104/pp.56.4.502.
3
E.B. Wilson Lecture, 1998. Eukaryotic RNAs: once more from the beginning.1998年E.B. 威尔逊讲座。真核生物RNA：再从头说起。
Mol Biol Cell. 1999 Jun;10(6):1685-92. doi: 10.1091/mbc.10.6.1685.
4
Addition of polyadenylate sequences to virus-specific RNA during adenovirus replication.在腺病毒复制过程中，向病毒特异性RNA添加聚腺苷酸序列。
Proc Natl Acad Sci U S A. 1971 Nov;68(11):2806-9. doi: 10.1073/pnas.68.11.2806.
5
An adenylic acid-rich sequence in messenger RNA of HeLa cells and its possible relationship to reiterated sites in DNA.海拉细胞信使核糖核酸中富含腺苷酸的序列及其与DNA中重复位点的可能关系。
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1321-5. doi: 10.1073/pnas.68.6.1321.
6
The synthesis of ribonucleic acid in immature rat uterus responding to oestradiol-17 beta.未成熟大鼠子宫对17β-雌二醇反应时核糖核酸的合成
Biochem J. 1971 Nov;125(2):605-14. doi: 10.1042/bj1250605.
7
Hybridization properties of DNA sequences directing the synthesis of messenger RNA and heterogeneous nuclear RNA.指导信使核糖核酸和不均一核核糖核酸合成的DNA序列的杂交特性。
J Cell Biol. 1971 Sep;50(3):774-86. doi: 10.1083/jcb.50.3.774.
8
Transcription rates of individual polytene chromosome bands: effects of gene dose and sex in Drosophila.果蝇中单个多线染色体带的转录速率：基因剂量和性别的影响
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9
[Structure and function of chromatin (author's transl)].染色质的结构与功能（作者译）
Klin Wochenschr. 1973 Jul 1;51(3):631-43. doi: 10.1007/BF01468167.
10
Double-stranded regions in heterogeneous nuclear RNA from Hela cells.来自海拉细胞的不均一核RNA中的双链区域。
Proc Natl Acad Sci U S A. 1972 Sep;69(9):2537-41. doi: 10.1073/pnas.69.9.2537.

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POLYRIBOSOMES IN NORMAL AND POLIOVIRUS-INFECTED HELA CELLS AND THEIR RELATIONSHIP TO MESSENGER-RNA.正常及脊髓灰质炎病毒感染的海拉细胞中的多核糖体及其与信使核糖核酸的关系
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ENTRANCE OF NEWLY FORMED MESSENGER RNA AND RIBOSOMES INTO HELA CELL CYTOPLASM.新形成的信使核糖核酸和核糖体进入海拉细胞细胞质。
J Mol Biol. 1965 Feb;11:187-201. doi: 10.1016/s0022-2836(65)80050-x.
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ISOLATION AND PURIFICATION OF UNDEGRADED RIBONUCLEIC ACIDS.未降解核糖核酸的分离与纯化
Biochim Biophys Acta. 1964 May 18;87:9-16. doi: 10.1016/0926-6550(64)90041-6.
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Demonstration of an unstable RNA and of a precursor to ribosomal RNA in HeLa cells.在海拉细胞中证实存在不稳定RNA和核糖体RNA前体。
Proc Natl Acad Sci U S A. 1963 Feb 15;49(2):240-8. doi: 10.1073/pnas.49.2.240.
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Complementary RNA in nucleus and cytoplasm of mouse liver cells.小鼠肝细胞细胞核与细胞质中的互补RNA。
Science. 1963 Jun 28;140(3574):1408-12. doi: 10.1126/science.140.3574.1408.
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Genetic regulatory mechanisms in the synthesis of proteins.蛋白质合成中的遗传调控机制。
J Mol Biol. 1961 Jun;3:318-56. doi: 10.1016/s0022-2836(61)80072-7.
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Amino acid metabolism in mammalian cell cultures.哺乳动物细胞培养中的氨基酸代谢
Science. 1959 Aug 21;130(3373):432-7. doi: 10.1126/science.130.3373.432.
8
Evidence for ribonucleic acid molecules restricted to the cell nucleus.核糖核酸分子局限于细胞核的证据。
Biochemistry. 1967 Jan;6(1):283-9. doi: 10.1021/bi00853a044.
9
Giant-size rapidly labeled nuclear ribonucleic acid and cytoplasmic messenger ribonucleic acid in immature duck erythrocytes.未成熟鸭红细胞中的巨大快速标记核糖核酸和细胞质信使核糖核酸
J Mol Biol. 1966 Sep;20(1):145-82. doi: 10.1016/0022-2836(66)90123-9.
10
Rapidly labeled HeLa cell nuclear RNA. II. Base composition and cellular localization of a heterogeneous RNA fraction.快速标记的海拉细胞核RNA。II. 一种不均一RNA组分的碱基组成和细胞定位
J Mol Biol. 1966 Aug;19(2):362-72. doi: 10.1016/s0022-2836(66)80010-4.

通过RNA-DNA杂交对海拉细胞中的不均一核RNA和多聚核糖体信使RNA进行比较。

A comparison between heterogeneous nuclear RNA and polysomal messenger RNA in HeLa cells by RNA-DNA hybridization.

作者信息

Soeiro R, Darnell J E

出版信息

J Cell Biol. 1970 Mar;44(3):467-75. doi: 10.1083/jcb.44.3.467.

DOI:10.1083/jcb.44.3.467
PMID:5415231
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2107980/
Abstract

Heterogeneous nuclear RNA (HnRNA) and mRNA from cytoplasmic polyribosomes of HeLa cells have been compared by RNA-DNA hybridization tests. 1 microg of HeLa cell DNA binds 0.05-0.10 microg of either HnRNA or mRNA. In addition, HeLa DNA that is preexposed to unlabeled HnRNA was found to have a reduced capacity to bind either HnRNA or mRNA. The results are compatible with considerable sequence similarity in the two types of RNA but, as is discussed, firm conclusions are precluded by imperfections of the hybridization reaction as presently employed.

摘要

通过RNA-DNA杂交试验，对来自HeLa细胞胞质多核糖体的不均一核RNA（HnRNA）和mRNA进行了比较。1微克HeLa细胞DNA可结合0.05 - 0.10微克的HnRNA或mRNA。此外，发现预先与未标记的HnRNA接触过的HeLa DNA结合HnRNA或mRNA的能力降低。这些结果与两种RNA在序列上有相当大的相似性相符，但是，如所讨论的，由于目前所用杂交反应的不完善，无法得出确凿的结论。