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10
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本文引用的文献

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EFFECT OF EPINEPHRINE ON THE MECHANICAL AND PHOSPHORYLASE ACTIVITY OF NORMO- AND HYPOTHERMIC HEARTS.
Circ Res. 1963 Sep;13:199-206. doi: 10.1161/01.res.13.3.199.
2
Effect of isoproterenol on contractions and phosphorylase activity of normo- and hypothermic cardiac muscle.
Arch Int Pharmacodyn Ther. 1967 Aug;168(2):296-303.
3
The interaction of quinidine with alpha and beta adrenergic receptors in the rat myocardium.
J Pharmacol Exp Ther. 1969 Feb;165(2):242-50.
4
[The influence of thyroid gland function on the pharmacological action of propranolol, adrenaline, noradrenaline and dinitrophenol].[甲状腺功能对普萘洛尔、肾上腺素、去甲肾上腺素及二硝基酚药理作用的影响]
Arch Int Pharmacodyn Ther. 1968 Dec;176(2):263-88.
5
Evidence favouring the existence of a single adrenergic receptor.支持单一肾上腺素能受体存在的证据。
Nature. 1968 Mar 16;217(5133):1077-8. doi: 10.1038/2171077a0.
6
Interactions between sympathomimetic amines and blocking agents on the rat ventricle strip.拟交感神经胺与阻断剂在大鼠心室肌条上的相互作用。
Arch Int Pharmacodyn Ther. 1966 Apr;160(2):379-89.
7
Myocardial alpha and beta adrenergic receptors as demonstrated by atrial functional refractory-period changes.通过心房功能不应期变化所证实的心肌α和β肾上腺素能受体
J Pharmacol Exp Ther. 1966 Nov;154(2):255-63.

离体蛙心α和β肾上腺素能受体的温度调节

Temperature modulation of alpha- and beta-adrenoceptors in the isolated frog heart.

作者信息

Buckley G A, Jordan C C

出版信息

Br J Pharmacol. 1970 Feb;38(2):394-8.

PMID:5417862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1702803/
Abstract
  1. The effects of adrenaline on the isolated frog's heart at 27 degrees C are not antagonized by phentolamine (1.5 x 10(-6)M) but are abolished at 7 degrees C.2. At 27 degrees C isoprenaline was more potent than noradrenaline, but at 7 degrees C noradrenaline was more potent than isoprenaline.3. Phenoxybenzamine (1.5 x 10(-5)M) or dibenamine (1.5 x 10(-5)M) at 7 degrees C abolished the work output induced by adrenaline. When the temperature was raised to 24 degrees C, adrenaline caused an increase in work output.4. It is concluded that in the isolated frog heart there are at least two pools of adrenoceptors, the availability of which can be governed by temperature.
摘要

  1. 在27摄氏度时，肾上腺素对离体青蛙心脏的作用不会被酚妥拉明（1.5×10⁻⁶M）拮抗，但在7摄氏度时会被消除。

  2. 在27摄氏度时，异丙肾上腺素比去甲肾上腺素更有效，但在7摄氏度时，去甲肾上腺素比异丙肾上腺素更有效。

  3. 在7摄氏度时，酚苄明（1.5×10⁻⁵M）或双苄胺（1.5×10⁻⁵M）会消除肾上腺素诱导的功输出。当温度升至24摄氏度时，肾上腺素会使功输出增加。

  4. 得出的结论是，在离体青蛙心脏中至少存在两类肾上腺素能受体，其可用性可受温度调控。