离体蛙心α和β肾上腺素能受体的温度调节
Temperature modulation of alpha- and beta-adrenoceptors in the isolated frog heart.
作者信息
Buckley G A, Jordan C C
出版信息
Br J Pharmacol. 1970 Feb;38(2):394-8.
Abstract
- The effects of adrenaline on the isolated frog's heart at 27 degrees C are not antagonized by phentolamine (1.5 x 10(-6)M) but are abolished at 7 degrees C.2. At 27 degrees C isoprenaline was more potent than noradrenaline, but at 7 degrees C noradrenaline was more potent than isoprenaline.3. Phenoxybenzamine (1.5 x 10(-5)M) or dibenamine (1.5 x 10(-5)M) at 7 degrees C abolished the work output induced by adrenaline. When the temperature was raised to 24 degrees C, adrenaline caused an increase in work output.4. It is concluded that in the isolated frog heart there are at least two pools of adrenoceptors, the availability of which can be governed by temperature.
摘要
在27摄氏度时，肾上腺素对离体青蛙心脏的作用不会被酚妥拉明（1.5×10⁻⁶M）拮抗，但在7摄氏度时会被消除。
在27摄氏度时，异丙肾上腺素比去甲肾上腺素更有效，但在7摄氏度时，去甲肾上腺素比异丙肾上腺素更有效。
在7摄氏度时，酚苄明（1.5×10⁻⁵M）或双苄胺（1.5×10⁻⁵M）会消除肾上腺素诱导的功输出。当温度升至24摄氏度时，肾上腺素会使功输出增加。
得出的结论是，在离体青蛙心脏中至少存在两类肾上腺素能受体，其可用性可受温度调控。
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