联合使用甲状腺素和三碘甲状腺原氨酸进行甲状腺替代治疗。
Combined thyroxine and triiodothyronine for thyroid replacement therapy.
作者信息
Taylor S, Kapur M, Adie R
出版信息
Br Med J. 1970 May 2;2(5704):270-1. doi: 10.1136/bmj.2.5704.270.
Abstract
Tablets containing 50mug. of thyroxine and 15mug. of triiodothyronine have been used to treat patients with hypothyroidism of varied aetiology. Following total thyroidectomy a daily dose of three tablets-that is, 150mug. of thyroxine and 45mug. of triiodothyronine-maintained patients in a euthyroid state and produced a protein-bound iodine level within the normal range. The preparation is preferable to dried thyroid because of uniformity of activity and speed of action, and when the patient is clinically euthyroid the P.B.I. falls within the normal range.
摘要
含50微克甲状腺素和15微克三碘甲状腺原氨酸的片剂已用于治疗病因各异的甲状腺功能减退患者。甲状腺全切除术后，每日服用三片——即150微克甲状腺素和45微克三碘甲状腺原氨酸——可使患者维持甲状腺功能正常状态，并使蛋白结合碘水平保持在正常范围内。由于活性均匀且作用迅速，该制剂比干甲状腺制剂更可取，而且当患者临床甲状腺功能正常时，蛋白结合碘会处于正常范围内。
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本文引用的文献
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DETERMINATION OF THYROXINE AND TRIIODOTHYRONINE IN COMMERCIAL PREPARATIONS OF DESICCATED THYROID AND THYROID EXTRACT.
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ANOMALOUS EFFECTS OF CERTAIN PREPARATIONS OF DESICCATED THYROID ON SERUM PROTEIN-BOUND IODINE.某些甲状腺干粉制剂对血清蛋白结合碘的异常影响。
N Engl J Med. 1964 Feb 27;270:439-42. doi: 10.1056/NEJM196402272700903.
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Effect of triiodothyronine administration on serum PBI in hypothyroid patients maintained on constant doses of thyroxine.
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Physiologic combinations of synthetic thyroid hormones in myxedema.
Clin Pharmacol Ther. 1965 Nov-Dec;6(6):710-5. doi: 10.1002/cpt196566710.
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