三碘甲状腺原氨酸与甲状腺素联合治疗甲状腺功能减退症的对照临床试验。
Controlled clinical trial of combined triiodothyronine and thyroxine in the treatment of hypothyroidism.
作者信息
Smith R N, Taylor S A, Massey J C
出版信息
Br Med J. 1970 Oct 17;4(5728):145-8. doi: 10.1136/bmj.4.5728.145.
Abstract
A -double-blind crossover trial of a combined preparation of triiodothyronine and thyroxine (1:4 ratio) compared with thyroxine alone was conducted with 99 patients previously stabilized on. thyroxine as treatment for hypothyroidism. Four patients were excluded during the trial and eight afterwards owing to gross deficiencies in taking the tablets. Of the remaining 87 patients 42 (48%) had no -preference for either medication, 29 (33%) preferred thyroxine alone, and 16 (18%) the combination. A high incidence of unpleasant symptoms was experienced during the two months' treatment with the combined preparation. The serum protein-bound iodine levels were lowered (mean reduction 1.8 mug./100 ml.) on the combination, but the labelled T(3)-resin sponge uptake values were not altered and remained in the normal range. on both treatments.
摘要
对99例之前已使用甲状腺素稳定治疗甲状腺功能减退症的患者进行了一项双盲交叉试验，比较了三碘甲状腺原氨酸与甲状腺素联合制剂（比例为1:4）和单独使用甲状腺素的效果。试验期间有4例患者被排除，之后又有8例因服药严重不足被排除。在其余87例患者中，42例（48%）对两种药物无偏好，29例（33%）更喜欢单独使用甲状腺素，16例（18%）更喜欢联合制剂。在使用联合制剂治疗的两个月期间，出现不愉快症状的发生率较高。联合制剂治疗时血清蛋白结合碘水平降低（平均降低1.8微克/100毫升），但标记的T（3）-树脂海绵摄取值未改变，两种治疗方法下均保持在正常范围内。
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A comparison of the thyroxine: tri-iodothyronine content and biological activity of thyroid from various species.不同物种甲状腺素：三碘甲状腺原氨酸含量及生物学活性的比较。
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Clinically inactive thyroid U.S.P. A preliminary report.美国药典临床无活性甲状腺。初步报告。
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The in vitro resin sponge uptake of triiodothyronine-I-131 from serum in thyroid disease and in pregnancy.甲状腺疾病及妊娠状态下血清中三碘甲状腺原氨酸-I-131的体外树脂海绵摄取情况。
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8
Why does anybody use thyroid B.P.?为什么有人会使用甲状腺血压（B.P.可能是血压blood pressure的缩写，但这里表述不太清晰，可能有误）？
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Thyroxin-triiodothyronine concentrations in thryoid powders.甲状腺粉中的甲状腺素 - 三碘甲状腺原氨酸浓度。
J Pharm Sci. 1966 Apr;55(4):390-3. doi: 10.1002/jps.2600550408.
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