三碘甲状腺原氨酸与甲状腺素联合治疗甲状腺功能减退症的对照临床试验。
Controlled clinical trial of combined triiodothyronine and thyroxine in the treatment of hypothyroidism.
作者信息
Smith R N, Taylor S A, Massey J C
出版信息
Br Med J. 1970 Oct 17;4(5728):145-8. doi: 10.1136/bmj.4.5728.145.
Abstract
A -double-blind crossover trial of a combined preparation of triiodothyronine and thyroxine (1:4 ratio) compared with thyroxine alone was conducted with 99 patients previously stabilized on. thyroxine as treatment for hypothyroidism. Four patients were excluded during the trial and eight afterwards owing to gross deficiencies in taking the tablets. Of the remaining 87 patients 42 (48%) had no -preference for either medication, 29 (33%) preferred thyroxine alone, and 16 (18%) the combination. A high incidence of unpleasant symptoms was experienced during the two months' treatment with the combined preparation. The serum protein-bound iodine levels were lowered (mean reduction 1.8 mug./100 ml.) on the combination, but the labelled T(3)-resin sponge uptake values were not altered and remained in the normal range. on both treatments.
摘要
对99例之前已使用甲状腺素稳定治疗甲状腺功能减退症的患者进行了一项双盲交叉试验，比较了三碘甲状腺原氨酸与甲状腺素联合制剂（比例为1:4）和单独使用甲状腺素的效果。试验期间有4例患者被排除，之后又有8例因服药严重不足被排除。在其余87例患者中，42例（48%）对两种药物无偏好，29例（33%）更喜欢单独使用甲状腺素，16例（18%）更喜欢联合制剂。在使用联合制剂治疗的两个月期间，出现不愉快症状的发生率较高。联合制剂治疗时血清蛋白结合碘水平降低（平均降低1.8微克/100毫升），但标记的T（3）-树脂海绵摄取值未改变，两种治疗方法下均保持在正常范围内。
相似文献
1
Controlled clinical trial of combined triiodothyronine and thyroxine in the treatment of hypothyroidism.三碘甲状腺原氨酸与甲状腺素联合治疗甲状腺功能减退症的对照临床试验。
Br Med J. 1970 Oct 17;4(5728):145-8. doi: 10.1136/bmj.4.5728.145.
2
Thyroid hormone replacement for central hypothyroidism: a randomized controlled trial comparing two doses of thyroxine (T4) with a combination of T4 and triiodothyronine.中枢性甲状腺功能减退症的甲状腺激素替代治疗：一项随机对照试验，比较两种剂量的甲状腺素（T4）与T4和三碘甲状腺原氨酸联合用药的效果。
J Clin Endocrinol Metab. 2007 Nov;92(11):4115-22. doi: 10.1210/jc.2007-0297. Epub 2007 Aug 21.
3
Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: a randomized controlled trial.左甲状腺素联合碘塞罗宁与单用左甲状腺素治疗原发性甲状腺功能减退症的比较：一项随机对照试验
JAMA. 2003 Dec 10;290(22):2952-8. doi: 10.1001/jama.290.22.2952.
4
Combined therapy with levothyroxine and liothyronine in two ratios, compared with levothyroxine monotherapy in primary hypothyroidism: a double-blind, randomized, controlled clinical trial.左甲状腺素与碘塞罗宁两种比例联合治疗与左甲状腺素单药治疗原发性甲状腺功能减退症的比较：一项双盲、随机、对照临床试验
J Clin Endocrinol Metab. 2005 May;90(5):2666-74. doi: 10.1210/jc.2004-2111. Epub 2005 Feb 10.
5
Thyroxine alone or thyroxine plus triiodothyronine replacement therapy for hypothyroidism.甲状腺素单药或甲状腺素联合三碘甲状腺原氨酸替代疗法治疗甲状腺功能减退症。
Nucl Med Commun. 2009 Aug;30(8):586-93. doi: 10.1097/MNM.0b013e32832c79e0.
6
Combined thyroxine/liothyronine treatment does not improve well-being, quality of life, or cognitive function compared to thyroxine alone: a randomized controlled trial in patients with primary hypothyroidism.与单独使用甲状腺素相比，联合使用甲状腺素/三碘甲状腺原氨酸治疗并不能改善原发性甲状腺功能减退患者的幸福感、生活质量或认知功能：一项随机对照试验。
J Clin Endocrinol Metab. 2003 Oct;88(10):4543-50. doi: 10.1210/jc.2003-030249.
7
Primary hypothyroidism.原发性甲状腺功能减退症
Clin Evid. 2002 Jun(7):548-54.
8
[Combination therapy of thyroxine and triiodothyronine in hypothyroid patients].
Ugeskr Laeger. 2018 May 7;180(19).
9
Hypothyroidism in the elderly: pathophysiology, diagnosis and treatment.老年人甲状腺功能减退症：病理生理学、诊断与治疗
Drugs Aging. 2005;22(1):23-38. doi: 10.2165/00002512-200522010-00002.
10
Combined thyroxine and triiodothyronine for thyroid replacement therapy.联合使用甲状腺素和三碘甲状腺原氨酸进行甲状腺替代治疗。
Br Med J. 1970 May 2;2(5704):270-1. doi: 10.1136/bmj.2.5704.270.
引用本文的文献
1
Clinical thyroidology: beyond the 1970s' TSH-T4 Paradigm.临床甲状腺学：超越20世纪70年代的促甲状腺激素-甲状腺素范式
Front Endocrinol (Lausanne). 2025 Jun 24;16:1529791. doi: 10.3389/fendo.2025.1529791. eCollection 2025.
2
Natural desiccated thyroid for the treatment of hypothyroidism?天然甲状腺干制剂治疗甲状腺功能减退症？
Front Endocrinol (Lausanne). 2024 Jan 8;14:1309159. doi: 10.3389/fendo.2023.1309159. eCollection 2023.
3
Progress Toward and Challenges Remaining for Thyroid Tissue Regeneration.甲状腺组织再生的进展和遗留挑战。
Endocrinology. 2023 Aug 28;164(10). doi: 10.1210/endocr/bqad136.
4
Are We Restoring Thyroid Hormone Signaling in Levothyroxine-Treated Patients With Residual Symptoms of Hypothyroidism?我们是否正在恢复左甲状腺素治疗后仍有甲状腺功能减退症状患者的甲状腺激素信号传导？
Endocr Pract. 2023 Jul;29(7):581-588. doi: 10.1016/j.eprac.2023.04.003.
5
Critical Approach to Hypothyroid Patients With Persistent Symptoms.对持续存在症状的甲状腺功能减退症患者的批判性方法。
J Clin Endocrinol Metab. 2023 Sep 18;108(10):2708-2716. doi: 10.1210/clinem/dgad224.
6
Thyroid Signaling Biomarkers in Female Symptomatic Hypothyroid Patients on Liothyronine versus Levothyroxine Monotherapy: A Randomized Crossover Trial.接受三碘甲状腺原氨酸与左旋甲状腺素单药治疗的有症状女性甲状腺功能减退患者的甲状腺信号生物标志物：一项随机交叉试验
J Thyroid Res. 2022 May 4;2022:6423023. doi: 10.1155/2022/6423023. eCollection 2022.
7
The Role of Inositol in Thyroid Physiology and in Subclinical Hypothyroidism Management.肌醇在甲状腺生理学和亚临床甲状腺功能减退症管理中的作用。
Front Endocrinol (Lausanne). 2021 May 10;12:662582. doi: 10.3389/fendo.2021.662582. eCollection 2021.
8
Liothyronine and levothyroxine prescribing in England: A comprehensive survey and evaluation.在英国，左甲状腺素和甲状腺素的处方情况：一项全面的调查和评估。
Int J Clin Pract. 2021 Sep;75(9):e14228. doi: 10.1111/ijcp.14228. Epub 2021 Jul 6.
9
Liothyronine and Desiccated Thyroid Extract in the Treatment of Hypothyroidism.左甲状腺素与甲状腺干制剂治疗甲状腺功能减退症。
Thyroid. 2020 Oct;30(10):1399-1413. doi: 10.1089/thy.2020.0153. Epub 2020 May 12.
10
Combination Thyroid Hormone Replacement; Knowns and Unknowns.联合甲状腺激素替代疗法：已知与未知
Front Endocrinol (Lausanne). 2019 Oct 22;10:706. doi: 10.3389/fendo.2019.00706. eCollection 2019.
本文引用的文献
1
DETERMINATION OF THYROXINE AND TRIIODOTHYRONINE IN COMMERCIAL PREPARATIONS OF DESICCATED THYROID AND THYROID EXTRACT.
J Clin Endocrinol Metab. 1965 Jul;25:949-56. doi: 10.1210/jcem-25-7-949.
2
THE EFFECT OF THYROXINE AND TRIIODOTHYRONINE TREATMENT ON THE RESIN UPTAKE OF I-131-THYROXINE AND TRIIODOTHYRONINE.甲状腺素和三碘甲状腺原氨酸治疗对 I-131-甲状腺素和三碘甲状腺原氨酸树脂摄取的影响。
Metabolism. 1964 Jun;13:557-61. doi: 10.1016/0026-0495(64)90144-1.
3
THYROID THERAPY OF MYXEDEMA: A COMPARISON OF VARIOUS AGENTS WITH A NOTE ON THE COMPOSITION OF THYROID SECRETION IN MAN.黏液性水肿的甲状腺疗法：多种药物的比较及关于人类甲状腺分泌物成分的注释
Ann Intern Med. 1964 Jan;60:79-87. doi: 10.7326/0003-4819-60-1-79.
4
A comparison of the thyroxine: tri-iodothyronine content and biological activity of thyroid from various species.不同物种甲状腺素：三碘甲状腺原氨酸含量及生物学活性的比较。
J Pharm Pharmacol. 1962 Dec;14:777-83. doi: 10.1111/j.2042-7158.1962.tb11176.x.
5
The chemical determination of liothyronine and thyroxine in enzymic hydrolysates of pork thyroid.猪甲状腺酶解产物中三碘甲状腺原氨酸和甲状腺素的化学测定
J Pharm Pharmacol. 1962 Sep;14:597-604. doi: 10.1111/j.2042-7158.1962.tb11144.x.
6
Clinically inactive thyroid U.S.P. A preliminary report.美国药典临床无活性甲状腺。初步报告。
N Engl J Med. 1962 Jan 18;266:136-7. doi: 10.1056/NEJM196201182660308.
7
The in vitro resin sponge uptake of triiodothyronine-I-131 from serum in thyroid disease and in pregnancy.甲状腺疾病及妊娠状态下血清中三碘甲状腺原氨酸-I-131的体外树脂海绵摄取情况。
J Clin Endocrinol Metab. 1960 Nov;20:1474-83. doi: 10.1210/jcem-20-11-1474.
8
Why does anybody use thyroid B.P.?为什么有人会使用甲状腺血压（B.P.可能是血压blood pressure的缩写，但这里表述不太清晰，可能有误）？
Lancet. 1961 Feb 11;1(7172):329-32. doi: 10.1016/s0140-6736(61)91498-2.
9
Metabolic and therapeutic effects of triiodothyronine.
J Am Med Assoc. 1956 Feb 25;160(8):646-52. doi: 10.1001/jama.1956.02960430036007.
10
Thyroxin-triiodothyronine concentrations in thryoid powders.甲状腺粉中的甲状腺素 - 三碘甲状腺原氨酸浓度。
J Pharm Sci. 1966 Apr;55(4):390-3. doi: 10.1002/jps.2600550408.
Zotero 插件