Kyu M H, Cavanagh J B
Br J Exp Pathol. 1970 Apr;51(2):217-27.
Porto-caval anastomoses have been made on male rats which survived for up to 38 weeks. The acute phase of the consequences of this operation was associated with rapid fall in liver and body weight and a slow fall in testicular weight. Appetite also was considerably reduced and the plasma ammonium nitrogen became set at a new level of 400-500 μg./100 ml. After 12 weeks all animals were tending to gain weight, and their appetite was returning towards normal. At this phase there was an increase in both liver and testicular weight and a slow fall in plasma ammonium nitrogen. It is considered that all these features were linked and probably dependent upon the return of portal blood to the liver through adhesions around the operation site. While the plasma ammonium nitrogen levels were lowered by antibiotic treatment, they could not be further raised by dietary means.
已对存活长达38周的雄性大鼠进行了门腔静脉吻合术。该手术后果的急性期与肝脏和体重迅速下降以及睾丸重量缓慢下降有关。食欲也大幅降低，血浆铵氮稳定在400 - 500μg./100 ml的新水平。12周后，所有动物都趋于体重增加，食欲也恢复正常。在此阶段，肝脏和睾丸重量均增加，血浆铵氮缓慢下降。据认为，所有这些特征都是相互关联的，可能取决于通过手术部位周围粘连使门静脉血回流至肝脏。虽然抗生素治疗可降低血浆铵氮水平，但无法通过饮食方式使其进一步升高。
