正常大鼠门腔静脉分流术后血清免疫球蛋白水平升高。
Increased serum immunoglobulin levels following portacaval shunt in the normal rat.
作者信息
Keraan M, Meyers O L, Engelbrecht G H, Hickman R, Saunders S J, Terblanche J
出版信息
Gut. 1974 Jun;15(6):468-72. doi: 10.1136/gut.15.6.468.
Normal rats subjected to end-to-side portacaval shunt showed decreased survival and weight gain, a progressive fall in serum albumin and reciprocal rise in serum gamma globulin when compared with sham-operated controls for 12 weeks. Antibacterial lipopolysaccharide antibody was detected in significant titre at the sixth and twelfth weeks. It is suggested that the elevated levels of gamma globulin and reversal of albumin/globulin ratios noted in these animals may represent an immune response to bacterial lipopolysaccharides released into the systemic circulation as a result of the portacaval shunt. The hyperglobulinaemia of cirrhosis in human subjects may have a similar aetiology.
与假手术对照组相比，接受端侧门腔静脉分流术的正常大鼠在12周内生存率降低、体重增加减少，血清白蛋白逐渐下降，血清γ球蛋白则相应升高。在第6周和第12周检测到显著滴度的抗菌脂多糖抗体。提示这些动物体内γ球蛋白水平升高和白蛋白/球蛋白比值逆转可能代表了对门腔静脉分流导致释放到体循环中的细菌脂多糖的免疫反应。人类肝硬化患者的高球蛋白血症可能有类似的病因。
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