Preisler H D, Bjornsson S, Mori M, Barcos M
Cell Differ. 1975 Dec;4(5):273-83. doi: 10.1016/0045-6039(75)90012-3.
Friend leukemia cells growing in suspension culture are thought to represent a population of primitive erythroid cells which have undergone malignant transformation. We have found that when growing in vivo or in plasma clots in vitro, these suspension culture cells can exhibit morphologic and enzymatic properties which are characteristic of primitive granulocytic cells. The microenvironment in which the tumor cells grow plays a major role in determining the direction of differentiation of these leukemia cells. Hence it appears likely that the Friend cell is in fact a neoplastic pluripotent hematopoietic stem cell.
悬浮培养中生长的弗氏白血病细胞被认为代表了一群经历了恶性转化的原始红细胞。我们发现，当这些悬浮培养细胞在体内或体外血浆凝块中生长时，它们可表现出原始粒细胞特有的形态学和酶学特性。肿瘤细胞生长的微环境在决定这些白血病细胞的分化方向中起主要作用。因此，弗氏细胞实际上可能是一种肿瘤性多能造血干细胞。
