对实验感染弗氏志贺菌的小鼠进行化疗。
Chemotherapy of mice experimentally infected with Shigella flexneri.
作者信息
Das N K, Chamberlain R E
出版信息
Appl Microbiol. 1970 May;19(5):776-80. doi: 10.1128/am.19.5.776-780.1970.
A chronic infection with Shigella flexneri 2a has been established in mice for the evaluation of compounds for therapeutic potential. Evidence of infection is indicated by prolonged symptomless excretion in the feces and by positive isolation of organisms from different segments of the intestinal tract and from mesenteric lymph nodes. Serum antibody titer reaches a maximum after 9 days of infection and remains at a low level until 32 days postinfection. In this model, five drugs used in human shigellosis were evaluated for efficacy. Ampicillin was found to be the most active followed by oxytetracycline and kanamycin. Neomycin and colistin were the least active in this system.
已在小鼠中建立了福氏志贺菌2a的慢性感染，以评估化合物的治疗潜力。感染的证据表现为粪便中长期无症状排泄，以及从肠道不同节段和肠系膜淋巴结中阳性分离出细菌。血清抗体滴度在感染9天后达到最大值，并在感染后32天一直保持在低水平。在该模型中，评估了用于人类志贺菌病的五种药物的疗效。发现氨苄青霉素活性最高，其次是土霉素和卡那霉素。新霉素和黏菌素在该系统中活性最低。
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