小鼠和豚鼠实验性肠道志贺氏菌和弧菌感染
Experimental enteric Shigella and Vibrio infections in mice and guinea pigs.
作者信息
FRETER R
出版信息
J Exp Med. 1956 Sep 1;104(3):411-8. doi: 10.1084/jem.104.3.411.
Abstract
A method has been devised for inhibiting the normal enteric flora, permitting long term asymptomatic enteric infections of mice and guinea pigs with streptomycin-resistant strains of Shigella flexneri or Vibrio cholerae. Introduction of a streptomycin-resistant strain of E. coli into the intestinal tract of experimental animals resulted in a rapid elimination of the enteric pathogens studied. No in vitro production of antibiotic substances by this coli strain could be demonstrated. Active and oral passive immunization did not noticeably influence the number of Shigella or Vibrio organisms recoverable from the feces of infected animals.
摘要
已设计出一种抑制正常肠道菌群的方法，可使小鼠和豚鼠长期无症状地感染对链霉素耐药的弗氏志贺菌或霍乱弧菌。将对链霉素耐药的大肠杆菌菌株引入实验动物肠道后，所研究的肠道病原体迅速被清除。未证明该大肠杆菌菌株在体外产生抗生素物质。主动免疫和口服被动免疫对从感染动物粪便中可回收的志贺菌或弧菌数量没有明显影响。
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本文引用的文献
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