溃疡性结肠炎和克罗恩病患者直肠活检中黏液物质的诊断价值。

Filipe M I, Dawson I

Gut. 1970 Mar;11(3):229-34. doi: 10.1136/gut.11.3.229.

Sixty-two biopsies from 36 patients with ulcerative colitis and 29 biopsies from 15 patients with Crohn's disease were studied with special reference to the content of neutral, acid non-sulphated and sulphated mucosubstances. A marked decrease was found in mucosubstance in patients with active ulcerative colitis and was related to the intensity of inflammation in the lamina propria but not to the duration of the disease. In patients with active Crohn's disease there was no corresponding decrease. Techniques for mucosubstances appear to be of value in differentiating between the two diseases in rectal biopsies.

对36例溃疡性结肠炎患者的62份活检样本以及15例克罗恩病患者的29份活检样本进行了研究，特别关注中性、酸性非硫酸化和硫酸化黏膜物质的含量。结果发现，活动期溃疡性结肠炎患者的黏膜物质显著减少，且与固有层炎症强度有关，而与疾病持续时间无关。活动期克罗恩病患者则没有相应的减少。黏膜物质检测技术似乎有助于通过直肠活检区分这两种疾病。