Ringelhann B, Konotey-Ahulu F, Dodu S R
J Clin Pathol. 1970 Mar;23(2):127-34. doi: 10.1136/jcp.23.2.127.
Iron absorption as measured by a faecal recovery method in young adult males living in a tropical zone was high, even in the absence of anaemia. There was an inverse relation between the iron absorption and the packed cell volume. The highest absorption was found in sickle cell anaemia patients, where the packed cell volume is the lowest. The incorporation of iron was also the fastest and greatest in this group. In the controls the iron absorbed accumulated in the marrow and the spleen on the first day; in the sickle cell anaemia group the spleen has an insignificant role in iron storage. The growing radioactivity in the liver parallels that of the heart in the group of sickle cell anaemia patients; however, it remains low in the spleen in the same group, implying a diminution of splenic blood flow. In the sickle cell haemoglobin C and the haemoglobin C patients, the liver and spleen have an intermediate position between that of the sickle cell anaemia group and the control group.
通过粪便回收法测量，生活在热带地区的年轻成年男性的铁吸收量很高，即使在没有贫血的情况下也是如此。铁吸收与红细胞压积之间呈负相关。镰状细胞贫血患者的铁吸收量最高，其红细胞压积最低。该组中铁的掺入也是最快且最多的。在对照组中，第一天吸收的铁积聚在骨髓和脾脏中；在镰状细胞贫血组中，脾脏在铁储存中作用不显著。镰状细胞贫血患者组中，肝脏放射性的增加与心脏同步；然而，同一组中脾脏的放射性仍然很低，这意味着脾血流量减少。在镰状细胞血红蛋白C和血红蛋白C患者中，肝脏和脾脏的情况介于镰状细胞贫血组和对照组之间。
