Eliopoulos G D, Andre S, Anagnou N P, Fessas P
Scand J Haematol. 1979 Nov;23(5):353-9. doi: 10.1111/j.1600-0609.1979.tb02732.x.
An intravenous injection of 548 microgram of killed Corynebacterium parvum (C. parvum) into C57BL mice led to a significant increase in the number of both committed stem cells (GM-CFC) and proliferating cells of bone marrow granulocytic series. This increase appeared 24 h after the injection of the bacterium, persisted in varying levels until the 4th week and was accompanied by a marked and prolonged granulocytosis. The proportion of GM-CFC in DNA synthesis was found to be increased 1, 2, and 5 d after injection of C. parvum. Increased serum lysozyme levels were observed on the 9th and 15th d. These findings suggest that C. parvum can stimulate granulopoiesis in the animal system. This property of the bacterium should be considered when a combined chemo-immunotherapy schedule has to be applied.
给C57BL小鼠静脉注射548微克灭活的短小棒状杆菌（C. parvum），可使定向干细胞（GM-CFC）和骨髓粒细胞系增殖细胞的数量显著增加。这种增加在注射细菌后24小时出现，以不同水平持续到第4周，并伴有明显且持久的粒细胞增多。发现注射C. parvum后1、2和5天，GM-CFC中DNA合成的比例增加。在第9天和第15天观察到血清溶菌酶水平升高。这些发现表明，C. parvum可刺激动物系统中的粒细胞生成。在必须应用联合化学免疫治疗方案时，应考虑该细菌的这一特性。
