Eliopoulos G, Andre S, Anagnou N P, Matsis C, Halpern B
Int J Cancer. 1979 Jan 15;23(1):114-8. doi: 10.1002/ijc.2910230120.
The intravenous administration of 548 microgram of killed Corynebacterium parvum (C. parvum) into C57BL mice leads to a significant decrease in the number of bone-marrow colony-forming-units in spleen (CFUs) as early as 12 h after the injection of the bacterium. This decrease persisted in varying degrees for 3 weeks. After an initial fall at 24 h, the splenic CFUs exhibited a rapid expansion and reached values 10 times higher than the control range on the ninth day. A significant rise in the number of circulating CFUs, reaching a first peak at 2 h and a second one on the fifth day, was also observed. The proliferative status of femoral CFUs was increased at 48 and 72 h, while that of splenic CFUs presented a significant increase only 48 h after the injection of C. parvum. The sequence of events which were observed in these experiments indicates that an accelerated migration of hemopoietic stem cells from bone marrow to spleen via the blood circulation has to take place.
给C57BL小鼠静脉注射548微克灭活的短小棒状杆菌（C. parvum）后，早在注射该细菌12小时后，脾脏中骨髓集落形成单位（CFUs）的数量就会显著减少。这种减少在3周内持续不同程度存在。在24小时出现初始下降后，脾脏CFUs迅速扩张，并在第9天达到比对照范围高10倍的值。还观察到循环CFUs数量显著增加，在2小时达到第一个峰值，在第5天达到第二个峰值。股骨CFUs的增殖状态在48小时和72小时增加，而脾脏CFUs的增殖状态仅在注射C. parvum后48小时显著增加。在这些实验中观察到的事件顺序表明，造血干细胞必须通过血液循环从骨髓加速迁移到脾脏。
