去势对雄性大鼠实验性胶质瘤诱导的影响。
The effects of castration on the induction of experimental gliomas in male rats.
作者信息
Hopewell J W
出版信息
Br J Cancer. 1970 Mar;24(1):187-90. doi: 10.1038/bjc.1970.21.
Abstract
Pellets of 3,4-benzopyrene were implanted into the brain of equal numbers of normal and castrated male rats. The position of the implant was carefully controlled so that it impinged on the mitotically active sub-ependymal plate.A high proportion of glial tumours (77.8%) were induced in normal male rats. The effects of castration were to reduce the incidence of tumoures (50%) and to increase the time interval between implantation and death from cerebral tumour.The implications from these results, as to the possible roles of testosterone, are discussed.
摘要
将3,4-苯并芘颗粒植入数量相等的正常雄性大鼠和去势雄性大鼠的大脑中。植入物的位置受到严格控制，使其作用于有丝分裂活跃的室管膜下板。正常雄性大鼠诱发了高比例的胶质瘤（77.8%）。去势的影响是降低肿瘤发生率（50%），并延长从植入到死于脑肿瘤的时间间隔。讨论了这些结果对于睾酮可能作用的意义。
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