Fox H, Sen D K
Br J Cancer. 1970 Mar;24(1):30-6. doi: 10.1038/bjc.1970.5.
A controlled study has been made of the constitutional background of 300 cases of endometrial adenocarcinoma. The control group was age matched and drawn from the same patient population pool as were the adenocarcinoma cases.Endometrial adenocarcinoma was shown to be associated unduly frequently with hypertension, nulliparity and the late age of menopause. No association was found between endometrial adenocarcinoma and obesity, diabetes mellitus, thyroid disease or extragenital malignant disease.It is suggested that these results are explicable on the basis that adrenal dysfunction may be an aetiological factor in the development of endometrial adenocarcinoma.
对300例子宫内膜腺癌患者的体质背景进行了对照研究。对照组在年龄上进行了匹配,且与腺癌病例来自相同的患者群体。结果显示,子宫内膜腺癌与高血压、未育及绝经年龄较晚的关联异常频繁。未发现子宫内膜腺癌与肥胖、糖尿病、甲状腺疾病或生殖器外恶性疾病之间存在关联。有人认为,基于肾上腺功能障碍可能是子宫内膜腺癌发生的一个病因学因素,这些结果是可以解释的。