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接触致敏期间豚鼠淋巴结中的二硝基苯酚缀合物

DNP conjugates in guinea-pig lymph nodes during contact sensitization.

作者信息

Parker D, Turk J L

出版信息

Immunology. 1970 Jun;18(6):855-64.

PMID:5428867
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1455740/
Abstract

Sensitization doses of [C]dinitrofluorobenzene (DNFB) were painted on the dorsum of guinea-pig ears and the total radioactivity in the draining lymph nodes was determined, at various time intervals, in the first 72 hours. Of this radioactivity, 25 per cent was found to be centrifuged off with the cell debris after homogenization of the nodes in saline. The radioactivity in the remaining saline soluble material was shown to be precipitated by trichloracetic acid; of this, the DNFB was found to be conjugated, to approximately the same degree, to both the lipid and the protein components of the nodes. The significance of these findings is discussed.

摘要

将致敏剂量的[C]二硝基氟苯（DNFB）涂抹在豚鼠耳部背面，并在最初72小时内的不同时间间隔测定引流淋巴结中的总放射性。在将淋巴结在盐水中匀浆后，发现其中25%的放射性随细胞碎片一起被离心去除。剩余盐溶性物质中的放射性被证明可被三氯乙酸沉淀；其中，发现DNFB与淋巴结的脂质和蛋白质成分结合的程度大致相同。讨论了这些发现的意义。

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Immunology. 1971 Jul;21(1):69-79.
2
Distribution of a contact sensitizer, 1-fluoro-2,4-dinitro-benzene, in the the tissues of the guinea-pig.接触性致敏剂1-氟-2,4-二硝基苯在豚鼠组织中的分布。
Immunology. 1972 Mar;22(3):381-92.
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Rosette-forming cells and the immunological response after DNCB, DNP-carrier and oxazolone sensitization.二硝基氯苯、二硝基苯载体及恶唑酮致敏后玫瑰花结形成细胞与免疫反应
Immunology. 1974 Feb;26(2):269-80.
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Contact sensitivity in the pig.猪的接触敏感性
Immunology. 1973 Dec;25(6):995-1009.
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Immunology. 1973 Sep;25(3):423-32.

本文引用的文献

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The relationship between delayed hypersensitivity and circulating antibody induced by protein antigens in guinea pigs.豚鼠中蛋白质抗原诱导的迟发型超敏反应与循环抗体之间的关系。
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14C AND 3H SPECIFIC ACTIVITIES BY BOMB COMBUSTION AND SCINTILLATION COUNTING BOMB COMBUSTION OF 14C AND 3H.通过燃烧弹燃烧和闪烁计数法测定14C和3H的比活度 14C和3H的燃烧弹燃烧
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Liquid scintillation counting of C-14-labelled CO2 with phenethylamine.用苯乙胺对 C - 14 标记的二氧化碳进行液体闪烁计数。
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Note on suitable solvent systems usable in the liquid scintillation counting of animal tissue.关于可用于动物组织液体闪烁计数的合适溶剂系统的说明。
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Studies of the mechanism of allergic eczematous contact dermatitis. II. Use of C14 labelled 2:4-dinitrochlorobenzene in guinea pigs.过敏性湿疹性接触性皮炎的机制研究。II. C14标记的2:4-二硝基氯苯在豚鼠中的应用。
J Invest Dermatol. 1958 Aug;31(2):97-102. doi: 10.1038/jid.1958.87.
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Experimental studies on the pathogenesis of contact eczema in the guinea-pig.豚鼠接触性湿疹发病机制的实验研究
Int Arch Allergy Appl Immunol. 1957;11(1-2):81-100. doi: 10.1159/000228405.
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The role of the carrier in the formation of complete antigens.载体在完全抗原形成中的作用。
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