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二硝基氯苯、二硝基苯载体及恶唑酮致敏后玫瑰花结形成细胞与免疫反应

Rosette-forming cells and the immunological response after DNCB, DNP-carrier and oxazolone sensitization.

作者信息

Scheper R J, Oort J

出版信息

Immunology. 1974 Feb;26(2):269-80.

PMID:4854174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1423082/
Abstract

Guinea-pigs have been sensitized with DNCB, DNP-guinea-pig serum and DNP-guinea-pig erythrocytes. Four, six and ten days after sensitization numbers of rosette-forming cells with DNP-erythrocytes were estimated in the draining lymph nodes. It was found that the numbers of DNP-erythrocyte RFC did not correlate with humoral immunity as estimated by haemagglutination assay, but did so with cell-mediated immunity estimated as delayed-type hypersensitivity. On the other hand histological examination of the draining lymph nodes gave no clear confirmation of such a relationship. Experiments on the antigenic specificity of RFC showed that after DNCB sensitization a clear increase in oxazolone-erythrocyte RFC and SRBC RFC can be found. These latter data suggest formation of RFC to be at least partly a non-specific phenomenon.

摘要

豚鼠已用二硝基氯苯（DNCB）、二硝基苯基 - 豚鼠血清和二硝基苯基 - 豚鼠红细胞致敏。致敏后4天、6天和10天，在引流淋巴结中估计与二硝基苯基红细胞形成玫瑰花结细胞的数量。结果发现，二硝基苯基红细胞玫瑰花结形成细胞（RFC）的数量与通过血凝试验估计的体液免疫不相关，但与作为迟发型超敏反应估计的细胞介导免疫相关。另一方面，对引流淋巴结的组织学检查并未明确证实这种关系。关于RFC抗原特异性的实验表明，在DNCB致敏后，可以发现恶唑酮红细胞RFC和绵羊红细胞RFC明显增加。这些数据表明RFC的形成至少部分是一种非特异性现象。

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本文引用的文献

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Protein patterns of red cell membranes from different mammalian species.不同哺乳动物物种红细胞膜的蛋白质模式。
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Vascular permeability responses in hypersensitivity. II. The reaction to 2, 4-dinitrochlorobenzene.超敏反应中的血管通透性反应。II. 对2,4-二硝基氯苯的反应。
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7
T and B rosette-forming cells.T 细胞和 B 细胞玫瑰花结形成细胞。
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The relationship between the morphology of rosette-forming cells and their mode of rosette formation.花环形成细胞的形态与其花环形成方式之间的关系。
Immunology. 1972 Feb;22(2):291-300.
9
Antigen recognition by T lymphocytes. Thymus and marrow dependence of spontaneous rosette forming cells in the mouse.T淋巴细胞的抗原识别。小鼠中自发形成玫瑰花结细胞对胸腺和骨髓的依赖性。
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The induction of delayed sensitivity to 2,4-dinitrophenyl conjugates in guinea pigs sensitized with DNCB.在用二硝基氯苯致敏的豚鼠中诱导对2,4-二硝基苯基结合物的迟发型超敏反应。
Dermatologica. 1972;144(1):19-26. doi: 10.1159/000252091.

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