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体外接触敏感性。从二硝基氯苯(DNCB)致敏淋巴细胞中由DNCB表皮组织获得的亚细胞器产生巨噬细胞抑制因子。

Contact sensitivity in vitro. The production of macrophage inhibition factors from DNCB sensitized lymphocytes by subcellular organelles obtained from DNCB epidermal tissue.

作者信息

Nishioka K, Amos H E

出版信息

Immunology. 1973 Sep;25(3):423-32.

Abstract

Actively allergized cells from guinea-pigs with contact sensitivity to DNCB were specifically triggered to produce the macrophage inhibition factors—antigen-dependent and non-antigen-dependent MIF by microsomal—DNCB complexes. The implication of this observation is that epidermal microsomal—DNCB complexes behave as complete antigens in a MIF assay system. It is therefore possible that such a combination acts as an immunogen in the induction of contact sensitivity to DNCB.

摘要

对二硝基氯苯(DNCB)有接触敏感性的豚鼠的活性致敏细胞,被微粒体-DNCB复合物特异性触发产生巨噬细胞抑制因子——抗原依赖性和非抗原依赖性巨噬细胞抑制因子(MIF)。这一观察结果的意义在于,表皮微粒体-DNCB复合物在MIF检测系统中表现为完全抗原。因此,这种组合有可能在诱导对DNCB的接触敏感性中作为免疫原起作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e836/1423066/7bb0f724d744/immunology00332-0086-a.jpg

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