Nishioka K, Amos H E
Immunology. 1973 Sep;25(3):423-32.
Actively allergized cells from guinea-pigs with contact sensitivity to DNCB were specifically triggered to produce the macrophage inhibition factors—antigen-dependent and non-antigen-dependent MIF by microsomal—DNCB complexes. The implication of this observation is that epidermal microsomal—DNCB complexes behave as complete antigens in a MIF assay system. It is therefore possible that such a combination acts as an immunogen in the induction of contact sensitivity to DNCB.
对二硝基氯苯(DNCB)有接触敏感性的豚鼠的活性致敏细胞,被微粒体-DNCB复合物特异性触发产生巨噬细胞抑制因子——抗原依赖性和非抗原依赖性巨噬细胞抑制因子(MIF)。这一观察结果的意义在于,表皮微粒体-DNCB复合物在MIF检测系统中表现为完全抗原。因此,这种组合有可能在诱导对DNCB的接触敏感性中作为免疫原起作用。