通过给予免疫球蛋白G增强兔的免疫反应。
Enhancement of the immune response in rabbits by administration of immunoglobulin-G.
作者信息
Dawe D L, Myers W L, Segre D
出版信息
Immunology. 1970 Jun;18(6):897-907.
Enhancement of the antibody response of rabbits to diphtheria toxoid (DT) and bovine serum albumin (BSA) was obtained by administration of IgG from either normal rabbit serum or serum of rabbits treated with Freund's complete adjuvant (FCA). It was shown that the concentration of IgG was greater in the serum of adjuvant treated rabbits than in normal rabbit serum, and that, in the case of BSA, greater enhancement of antibody formation was provided by the IgG derived from a volume of serum from adjuvant-treated rabbits than by the IgG from an equal volume of normal serum. Interpretation of these results within the framework of the natural selection model of antibody production provides a mechanism of action for Freund's adjuvant. Attempts to specifically remove the adjuvant effect of IgG for BSA by absorption with insoluble, polymerized BSA were unsuccessful. However, specific anti-BSA antibody was recovered from normal IgG by elution from the immunosorbent. This material is thought to represent natural antibody of the IgG class.
通过给予来自正常兔血清或用弗氏完全佐剂（FCA）处理的兔血清中的IgG，可增强兔对白喉类毒素（DT）和牛血清白蛋白（BSA）的抗体反应。结果表明，经佐剂处理的兔血清中IgG的浓度高于正常兔血清，并且就BSA而言，来自经佐剂处理的兔一定体积血清中的IgG比来自等体积正常血清中的IgG对抗体形成的增强作用更大。在抗体产生的自然选择模型框架内对这些结果的解释为弗氏佐剂提供了一种作用机制。试图通过用不溶性聚合BSA吸附来特异性去除IgG对BSA的佐剂效应未成功。然而，通过从免疫吸附剂上洗脱，从正常IgG中回收了特异性抗BSA抗体。这种物质被认为代表IgG类的天然抗体。
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