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与血清抗半抗原抗体的特异性相比，细胞免疫反应的半抗原特异性。

Hapten specificity of cellular immune responses as compared with the specificity of serum anti-hapten antibody.

作者信息

Paul W E, Siskind G W

出版信息

Immunology. 1970 Jun;18(6):921-30.

PMID:5428869
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1455735/
Abstract

Comparative specificity data have been presented for the interaction of anti-hapten antibody with a series of structurally related haptens and for the stimulation by hapten-guinea pig albumin (GPA) conjugates of DNA synthesis in lymph node cell cultures from guinea pigs immunized with a given conjugate. A good correlation in the specificity of serum anti-hapten antibody and in the specificity of stimulation of DNA synthesis has been demonstrated. Thus, mutual serologic and stimulatory cross-reactivity exist between the aminocaproates and GPA conjugates of the p-iodophenysulfonyl and toluenesulfonyl groups. Poor or undetectable serologic and stimulatory cross reactivity exist in the other combinations tested. The data is consistent with the notion that the interaction of antigen with an antibody-like cellular receptor is crucial to the elicitation of cellular immune responses.

摘要

已给出关于抗半抗原抗体与一系列结构相关半抗原相互作用的比较特异性数据，以及关于用特定偶联物免疫的豚鼠淋巴结细胞培养物中，半抗原 - 豚鼠白蛋白（GPA）偶联物对DNA合成的刺激作用的数据。血清抗半抗原抗体的特异性与DNA合成刺激的特异性之间已证明存在良好的相关性。因此，对氨基己酸盐与对碘苯磺酰基和甲苯磺酰基的GPA偶联物之间存在相互的血清学和刺激交叉反应性。在测试的其他组合中，血清学和刺激交叉反应性较差或无法检测到。这些数据与抗原与抗体样细胞受体的相互作用对于引发细胞免疫反应至关重要这一观点一致。

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Hapten specificity of cellular immune responses as compared with the specificity of serum anti-hapten antibody.与血清抗半抗原抗体的特异性相比，细胞免疫反应的半抗原特异性。
Immunology. 1970 Jun;18(6):921-30.
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Antigen-macrophage interaction. I. Hapten-specific inhibition of antigen interaction with macrophages from immune animals.抗原-巨噬细胞相互作用。I. 半抗原特异性抑制免疫动物来源的巨噬细胞与抗原的相互作用。
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[The effects of haptenic presentation on B and T cell responses].[半抗原呈递对B细胞和T细胞反应的影响]
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引用本文的文献

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Lymphocyte proliferation in vitro induced by hapten autologous protein conjugates. I. A study on the class of lymphocytes responding in vitro and on the nature and specificity of their receptors.半抗原自体蛋白缀合物诱导的体外淋巴细胞增殖。I. 体外应答淋巴细胞类别及其受体性质和特异性的研究
J Exp Med. 1974 Mar 1;139(3):732-53. doi: 10.1084/jem.139.3.732.
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Idiotypic analysis of lymphocytes in vitro. I. Specificity and heterogeneity of B and T lymphocytes reactive with anti-idiotypic antibody.体外淋巴细胞的独特型分析。I. 与抗独特型抗体反应的B淋巴细胞和T淋巴细胞的特异性及异质性。
J Exp Med. 1976 Apr 1;143(4):846-60. doi: 10.1084/jem.143.4.846.
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Immune response gene control of determinant selection. I. Intramolecular mapping of the immunogenic sites on insulin recognized by guinea pig T and B cells.决定簇选择的免疫反应基因控制。I. 豚鼠T细胞和B细胞识别的胰岛素上免疫原性位点的分子内定位。
J Exp Med. 1977 Mar 1;145(3):726-42. doi: 10.1084/jem.145.3.726.
4
Immune interferon induced by phytohemagglutinin in nude mouse spleen cells.植物血凝素在裸鼠脾细胞中诱导产生的免疫干扰素。
Infect Immun. 1978 Sep;21(3):966-72. doi: 10.1128/iai.21.3.966-972.1978.

本文引用的文献

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AN IN VITRO SYSTEM FOR THE STUDY OF THE MECHANISM OF ANTIGENIC STIMULATION IN THE SECONDARY RESPONSE.用于研究二次反应中抗原刺激机制的体外系统。
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Immunological specificity of delayed and immediate hypersensitivity reactions.迟发型和速发型超敏反应的免疫特异性
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5
The carbohydrate of gamma-globulin and myeloma proteins.γ-球蛋白和骨髓瘤蛋白的碳水化合物
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6
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7
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J Immunol. 1969 Sep;103(3):625-7.
8
Affinity of radioiodinated bovine serum albumin for lymphoid cells. Binding of I-125-BSA to lymphoid cells of immune mice.放射性碘化牛血清白蛋白对淋巴细胞的亲和力。I-125标记的牛血清白蛋白与免疫小鼠淋巴细胞的结合。
Isr J Med Sci. 1969 Mar-Apr;5(2):217-29.
9
The interaction of hapten-coupled bacteriophage phi-X-174 with antihapten antibody.半抗原偶联噬菌体φ-X-174与抗半抗原抗体的相互作用。
Isr J Med Sci. 1969 Mar-Apr;5(2):163-70.
10
Specific inactivation of antigen-reactive cells with 125I-labelled antigen.用125I标记的抗原特异性灭活抗原反应性细胞。
Nature. 1969 Jun 28;222(5200):1291-2. doi: 10.1038/2221291a0.

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