豚鼠对高度取代的二硝基苯基-人γ球蛋白的细胞和体液反应的半抗原及载体特异性

Hapten and carrier specificities of cellular and humoral responses to highly substituted dinitrophenyl-human gamma-globulins in guinea-pigs.

作者信息

Neveu P J, Borduas A G

出版信息

Immunology. 1975 Dec;29(6):1145-51.

PMID:53199

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1446026/

Abstract

Delayed hypersensitivity (DH) and antibody reactions to the carrier and to the hapten have been studied in guinea-pigs immunized with different doses of highly substituted dinitrophenyl-human gamma-globulins (DNP56-HGG) in Freund's complete adjuvant (FCA). The results confirm that DH reactions are specific for the carrier while antibody-mediated reactions are specific for the hapten in the early stages of the immune response. Later in the response, however, DH reactions to the hapten as well as a transient humoral reaction to the carrier could be observed. T cells specific for the hapten and B cells specific for the carrier are therefore triggered after a single infection of a highly substituted hapten-carrier conjugate in FCA. Their regulatory functions in the immune response to hapten-carrier conjugates are discussed.

摘要

在豚鼠中，研究了用不同剂量的高取代二硝基苯基 - 人γ - 球蛋白（DNP56 - HGG）在弗氏完全佐剂（FCA）中免疫后，对载体和半抗原的迟发型超敏反应（DH）及抗体反应。结果证实，在免疫反应早期，DH反应对载体具有特异性，而抗体介导的反应对半抗原有特异性。然而，在反应后期，可观察到对半抗原的DH反应以及对载体的短暂体液反应。因此，在FCA中单次注射高取代半抗原 - 载体偶联物后，会触发对半抗原有特异性的T细胞和对载体有特异性的B细胞。讨论了它们在对半抗原 - 载体偶联物免疫反应中的调节功能。

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Hapten and carrier specificities of cellular and humoral responses to highly substituted dinitrophenyl-human gamma-globulins in guinea-pigs.豚鼠对高度取代的二硝基苯基-人γ球蛋白的细胞和体液反应的半抗原及载体特异性

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Selective roles of thymus-derived lymphocytes in the antibody response. I. Differential suppressive effect of carrier-primed T cells on hapten-specific IgM and IgG antibody responses.胸腺来源淋巴细胞在抗体应答中的选择性作用。I. 载体致敏T细胞对半抗原特异性IgM和IgG抗体应答的差异抑制作用。

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Immunodeviation by passive antibody, an expression of selective immunodepression. II. Action of guinea pig IgG1 and IgG2 anticarrier antibodies.被动抗体引起的免疫偏离，一种选择性免疫抑制的表现。II. 豚鼠IgG1和IgG2抗载体抗体的作用。

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Proc Natl Acad Sci U S A. 1972 Dec;69(12):3774-8. doi: 10.1073/pnas.69.12.3774.

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Functional specificity of antigen-binding receptors of lymphocytes.淋巴细胞抗原结合受体的功能特异性。

Transplant Rev. 1970;5:130-66. doi: 10.1111/j.1600-065x.1970.tb00359.x.

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Modulation of the immune response by passive antibodies. I. Anti-hapten antibodies enhanced delayed hypersensitivity to the carrier and depressed antibody synthesis to the hapten.被动抗体对免疫反应的调节。I. 抗半抗原抗体增强对载体的迟发型超敏反应并抑制对半抗原的抗体合成。

Int Arch Allergy Appl Immunol. 1975;48(5):698-705. doi: 10.1159/000231357.

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