豚鼠对高度取代的二硝基苯基-人γ球蛋白的细胞和体液反应的半抗原及载体特异性
Hapten and carrier specificities of cellular and humoral responses to highly substituted dinitrophenyl-human gamma-globulins in guinea-pigs.
作者信息
Neveu P J, Borduas A G
出版信息
Immunology. 1975 Dec;29(6):1145-51.
Delayed hypersensitivity (DH) and antibody reactions to the carrier and to the hapten have been studied in guinea-pigs immunized with different doses of highly substituted dinitrophenyl-human gamma-globulins (DNP56-HGG) in Freund's complete adjuvant (FCA). The results confirm that DH reactions are specific for the carrier while antibody-mediated reactions are specific for the hapten in the early stages of the immune response. Later in the response, however, DH reactions to the hapten as well as a transient humoral reaction to the carrier could be observed. T cells specific for the hapten and B cells specific for the carrier are therefore triggered after a single infection of a highly substituted hapten-carrier conjugate in FCA. Their regulatory functions in the immune response to hapten-carrier conjugates are discussed.
在豚鼠中，研究了用不同剂量的高取代二硝基苯基 - 人γ - 球蛋白（DNP56 - HGG）在弗氏完全佐剂（FCA）中免疫后，对载体和半抗原的迟发型超敏反应（DH）及抗体反应。结果证实，在免疫反应早期，DH反应对载体具有特异性，而抗体介导的反应对半抗原有特异性。然而，在反应后期，可观察到对半抗原的DH反应以及对载体的短暂体液反应。因此，在FCA中单次注射高取代半抗原 - 载体偶联物后，会触发对半抗原有特异性的T细胞和对载体有特异性的B细胞。讨论了它们在对半抗原 - 载体偶联物免疫反应中的调节功能。
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