Sullman S F, Armstrong S J, Zuckerman A J, Rees K R
Br J Exp Pathol. 1970 Jun;51(3):314-6.
The cytotoxicity of aflatoxins G and B to cultured human embryo liver cells and of aflatoxin B to cultured adult liver cells, to cells of a semicontinuous diploid liver cell line and to a diploid lung cell line have been determined. Aflatoxins B and G were found to be considerably less toxic to human embryo liver cells than aflatoxin B and the LD's were 35 and 10 μg./ml. respectively after 48 hr exposure to the toxin. Human adult liver cells in culture, cells of the liver cell line and lung cells were much less sensitive to the action of aflatoxin B than embryo liver cells. These results have been compared with those previously reported for B and G and the reasons for the variation in toxicity observed are discussed.
已测定黄曲霉毒素G和B对培养的人胚胎肝细胞的细胞毒性，以及黄曲霉毒素B对培养的成人肝细胞、半连续二倍体肝细胞系细胞和二倍体肺细胞系细胞的细胞毒性。发现黄曲霉毒素B和G对人胚胎肝细胞的毒性远低于黄曲霉毒素B，在接触毒素48小时后，其半数致死量分别为35和10微克/毫升。培养的成人肝细胞、肝细胞系细胞和肺细胞对黄曲霉毒素B作用的敏感性远低于胚胎肝细胞。已将这些结果与先前报道的关于B和G的结果进行了比较，并讨论了观察到的毒性差异的原因。
