黄曲霉毒素B1、G1和G2对大鼠肝脏蛋白质及核酸合成的影响。
The effect of the aflatoxins B1, G1, and G2 on protein and nucleic acid synthesis in rat liver.
作者信息
Clifford J I, Rees K R, Stevens M E
出版信息
Biochem J. 1967 Apr;103(1):258-61. doi: 10.1042/bj1030258.
Abstract
A comparison has been made of the difference spectra obtained by causing various aflatoxins (B(1), G(1) and G(2)) to interact with calf-thymus DNA. The effect of these toxins on RNA and protein synthesis by rat-liver slices has been measured. The extent of their inhibitory action on the synthetic reactions was proportional to the degree of spectral shift obtained with their interaction with DNA. It is proposed that their toxicity depends on this interaction. It was demonstrated that the RNA polymerase of nucleoli isolated from the livers of aflatoxin B(1)-poisoned rats was inhibited. This finding is in agreement with the proposed mechanism for the hepatotoxic action of aflatoxin.
摘要
对通过使各种黄曲霉毒素（B₁、G₁和G₂）与小牛胸腺DNA相互作用而获得的差示光谱进行了比较。测定了这些毒素对大鼠肝脏切片RNA和蛋白质合成的影响。它们对合成反应的抑制作用程度与它们与DNA相互作用所获得的光谱位移程度成正比。有人提出它们的毒性取决于这种相互作用。已证明从黄曲霉毒素B₁中毒大鼠肝脏分离的核仁RNA聚合酶受到抑制。这一发现与所提出的黄曲霉毒素肝毒性作用机制一致。
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Further studies on the carcinogenic and growth-inhibitory activity of lactones and related substances.内酯及相关物质的致癌和生长抑制活性的进一步研究。
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