David-West T S
Br J Exp Pathol. 1970 Jun;51(3):332-9.
Time course studies intended to throw some light on the pathogenesis of some recently isolated Nigerian arboviruses were conducted by following the production of infective virus and complement-fixing (CF) antigen and correlating these with pathological changes in the brain and in the liver of suckling white Swiss mice. Two prototypes of the Nigerian arboviruses were employed: IB.AR.1792 (Dugbe) a hitherto undescribed arbovirus, isolated from and IB.AR.2012 (Thogoto) isolated from Following infection with virus 1792, titres of both infective virus and CF antigen increased rapidly in the brain. Infective virus was also produced in the liver but CF antigen was virtually negative. With virus 2012 infection, infective virus and CF antigen titres rose rapidly in the liver. But in the brain although infective virus was produced to a high titre, CF antigen was not demonstrated. Histopathological examination showed a positive correlation between the presence of CF antigen (and not infective virus ) and pathologic changes. There was encephalitis and cell degeneration in brain infected with virus 1792. The striking pathological changes in liver infected with virus 2012 were proliferation of the bile ducts, congested vessels and dilation of the sinusoids.
通过追踪感染性病毒和补体结合（CF）抗原的产生，并将这些与乳鼠瑞士小白鼠大脑和肝脏的病理变化相关联，进行了时间进程研究，旨在阐明一些最近分离出的尼日利亚虫媒病毒的发病机制。使用了两种尼日利亚虫媒病毒的原型：IB.AR.1792（杜贝病毒），一种迄今未描述的虫媒病毒，从……分离得到；以及IB.AR.2012（托戈托病毒），从……分离得到。用病毒1792感染后，大脑中感染性病毒和CF抗原的滴度迅速升高。肝脏中也产生了感染性病毒，但CF抗原实际上呈阴性。用病毒2012感染后，肝脏中感染性病毒和CF抗原滴度迅速上升。但在大脑中，尽管产生了高滴度的感染性病毒，但未检测到CF抗原。组织病理学检查显示CF抗原（而非感染性病毒）的存在与病理变化之间存在正相关。感染病毒1792的大脑出现脑炎和细胞变性。感染病毒2012的肝脏中显著的病理变化是胆管增生、血管充血和肝血窦扩张。
