David-West T S, Smith J A
Br J Exp Pathol. 1971 Apr;52(2):114-21.
A sequential and quantitative survey of brain and liver of suckling mice for infective virus and complement-fixing antigen, after infection with yellow fever virus, showed that while there was progressive increase of infective virus content in both organs, only the brain showed a corresponding rise in CF antigen. Histopathological examination revealed that the liver was not significantly involved. The target organ was the brain, where the progressive pathological changes culminated in an acute encephalitis by the 3rd day of experiment. Organ destruction began with the molecular layer of the grey matter. But by the 4th day after infection the entire cerebral cortex was involved. At the initial stages the hippocampus was particularly affected. Tissue damage did not appear to be entirely due to the differential quantitative localization of infective virus. It was hypothesized that the CF antigen acting singly or in conjunction with some hypothetical proteins may be principally involved in the pathological outcome of the disease.
在用黄热病病毒感染乳鼠后，对其脑和肝进行了连续定量的感染性病毒和补体结合抗原检测，结果显示，虽然两个器官中的感染性病毒含量都在逐渐增加，但只有脑内的补体结合（CF）抗原相应升高。组织病理学检查表明，肝脏未受到明显影响。靶器官是脑，在实验第3天，逐渐发展的病理变化最终导致急性脑炎。器官破坏始于灰质分子层。但在感染后第4天，整个大脑皮层都受到了影响。在初始阶段，海马体受到的影响尤为明显。组织损伤似乎并不完全是由于感染性病毒的差异定量定位所致。据推测，单独起作用或与某些假定蛋白质共同作用的CF抗原可能主要参与了该疾病的病理过程。
