• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Increased release of gut glucagon in reactive hypoglycaemia.反应性低血糖症中肠道胰高血糖素释放增加。
Br Med J. 1970 Jun 20;2(5711):706-7. doi: 10.1136/bmj.2.5711.706.
2
Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of Type II (non-insulin-dependent) diabetic parents: evidence of several aberrations.II型（非胰岛素依赖型）糖尿病患者后代的24小时胰岛素分泌率、循环燃料底物浓度及肠道肠促胰岛素激素：多种异常表现的证据
Diabetologia. 1999 Nov;42(11):1314-23. doi: 10.1007/s001250051444.
3
Restored synergistic entero-hormonal response after addition of dietary fibre to patients with impaired glucose tolerance and reactive hypoglycaemia.在糖耐量受损和反应性低血糖患者中添加膳食纤维后恢复的协同肠-激素反应。
Diabete Metab. 1982 Sep;8(3):217-22.
4
Increased gut glucagon release as pathogenetic factor in reactive hypoglycaemia?
Lancet. 1973 Jan 20;1(7795):116-8. doi: 10.1016/s0140-6736(73)90193-1.
5
Glucose-dependent insulinotropic polypeptide: effects on insulin and glucagon secretion in humans.葡萄糖依赖性促胰岛素多肽：对人体胰岛素和胰高血糖素分泌的影响
Dan Med J. 2016 Apr;63(4).
6
Patients With Long-QT Syndrome Caused by Impaired -Encoded K11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia.由KCNE1编码的K11.1钾通道功能受损引起的长QT综合征患者，其内分泌胰腺和肠促胰岛素功能亢进，并伴有反应性低血糖。
Circulation. 2017 May 2;135(18):1705-1719. doi: 10.1161/CIRCULATIONAHA.116.024279. Epub 2017 Feb 24.
7
Effects of total pancreatectomy on the secretion of gut glucagon in humans.全胰切除术对人体肠道胰高血糖素分泌的影响。
Jpn J Surg. 1983 Mar;13(2):122-9. doi: 10.1007/BF02469532.
8
Insulin response to carbohydrate ingestion after gastric surgery with special reference to hypoglycaemia.胃手术后碳水化合物摄入后的胰岛素反应，特别提及低血糖症。
Gut. 1969 Oct;10(10):825-30. doi: 10.1136/gut.10.10.825.
9
Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers.在健康志愿者进行的高胰岛素-阶梯式低血糖钳夹实验中，胰高血糖素样肽1对对抗调节激素反应、认知功能及胰岛素分泌的影响。
J Clin Endocrinol Metab. 2002 Mar;87(3):1239-46. doi: 10.1210/jcem.87.3.8355.
10
Gut glucagon and reactive hypoglycaemia.肠道胰高血糖素与反应性低血糖症。
Lancet. 1973 Jan 27;1(7796):202. doi: 10.1016/s0140-6736(73)90030-5.

引用本文的文献

1
The glucagon-like polypeptides - order out of chaos?
Diabetologia. 1980;18(2):85-8. doi: 10.1007/BF00290482.
2
The effects of glucagon, secretin, pancreozymin and pentagastrin on the hepatic arterial vascular bed of the dog.胰高血糖素、促胰液素、促胰酶素和五肽胃泌素对犬肝动脉血管床的作用。
Br J Pharmacol. 1977 Jan;59(1):147-56. doi: 10.1111/j.1476-5381.1977.tb06989.x.
3
Increased glucose disposal after jejuno-ileostomy.
Diabetologia. 1979 Jan;16(1):31-4. doi: 10.1007/BF00423147.
4
Identification of glucagon in the gastrointestinal tract.胃肠道中胰高血糖素的鉴定。
J Clin Invest. 1975 Jul;56(1):135-45. doi: 10.1172/JCI108062.

本文引用的文献

1
Spontaneous hypoglycemia.
Am J Med. 1955 Sep;19(3):460-78. doi: 10.1016/0002-9343(55)90130-3.
2
Plasma insulin levels during reactive hypoglycemia.反应性低血糖期间的血浆胰岛素水平。
Diabetes. 1966 Jan;15(1):1-4. doi: 10.2337/diab.15.1.1.
3
The gastrointestinal stimulus to insulin release. I. Secretin.胃肠道对胰岛素释放的刺激。I. 促胰液素。
J Clin Invest. 1969 Aug;48(8):1453-60. doi: 10.1172/JCI106111.
4
Effects of secretin, pancreozymin, or gastrin on the response of the endocrine pancreas to administration of glucose or arginine in man.促胰液素、缩胆囊素或胃泌素对人体内分泌胰腺对葡萄糖或精氨酸给药反应的影响。
J Clin Invest. 1969 Apr;48(4):745-57. doi: 10.1172/JCI106032.
5
New ideas concerning the physiologic roles of glucagon.
Am J Med Sci. 1968 May;255:273-6. doi: 10.1097/00000441-196805000-00001.
6
Characterization of the responses of circulating glucagon-like immunoreactivity to intraduodenal and intravenous administration of glucose.循环中胰高血糖素样免疫活性对十二指肠内和静脉内给予葡萄糖的反应特征
J Clin Invest. 1968 Jan;47(1):48-65. doi: 10.1172/JCI105714.
7
Pathophysiology of post-gastrectomy hypoglycaemia.胃切除术后低血糖的病理生理学
Br Med J. 1969 Nov 1;4(5678):257-9. doi: 10.1136/bmj.4.5678.257.
8
Intestinal factors in the control of insulin secretion.胰岛素分泌调控中的肠道因素。
J Clin Endocrinol Metab. 1965 Oct;25(10):1317-24. doi: 10.1210/jcem-25-10-1317.
9
A simplified technique for the determination of growth hormone dependent sulfation factor, using intact animals.一种使用完整动物测定生长激素依赖性硫酸化因子的简化技术。
Acta Endocrinol (Copenh). 1968 Apr;57(4):557-64. doi: 10.1530/acta.0.0570557.

反应性低血糖症中肠道胰高血糖素释放增加。

Increased release of gut glucagon in reactive hypoglycaemia.

作者信息

Rehfeld J F, Heding L G

出版信息

Br Med J. 1970 Jun 20;2(5711):706-7. doi: 10.1136/bmj.2.5711.706.

DOI:10.1136/bmj.2.5711.706
PMID:5429655
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1700662/
Abstract

A patient with reactive hypoglycaemia showed hypersecretion of insulin in response to enteral beta-cell stimulation. Increased levels of gut glucagon-like immunoreactivity in serum were demonstrated by use of specific antisera. Other measurable hormones influencing carbohydrate metabolism were within normal limits. It is suggested that gut glucagon-like immunoreactivity may be of pathogenetic significance in reactive hypoglycaemia.

摘要

一名反应性低血糖患者在接受肠内β细胞刺激后出现胰岛素分泌过多。通过使用特异性抗血清，证实血清中肠胰高血糖素样免疫反应性水平升高。其他影响碳水化合物代谢的可测量激素均在正常范围内。提示肠胰高血糖素样免疫反应性可能在反应性低血糖的发病机制中具有重要意义。