Monnier L H, Colette C, Aguirre L, Orsetti A, Combeaux D
Diabete Metab. 1982 Sep;8(3):217-22.
Although some dietary fibres (DF) improve glucose tolerance by slowing carbohydrate absorption, other mechanisms are certainly involved. Some of the entero-hormonal responses after DF were investigated in six patients with impaired glucose tolerance and reactive hypoglycaemia. All patients received two different breakfasts, each containing 25 g of starch supplied either as white bread (WB) or a fibre-enriched bread preparation (FB): 4 g hemicellulose and 4 g guar. Metabolic and hormonal responses were evaluated over 5 hours. Compared to WB, the FB had a blunting effect on the resulting blood glucose peak (116 +/- 9 mg/100 ml with FB vs. 148 +/- 15 with WB P less than 0.025) or trough (88 +/- 3 mg/100 ml with FB vs. 79 +/- 5 with WB), and upon the insulin response at 60 min (20 +/- 4 micro U/ml with FB vs. 70 +/- 20 with WB). Gut glucagon immunoreactivity was diminished with FB at 90 min (185 +/- 39 vs. 242 +/- 42 P less than 0.05) and 150 min (180 +/- 39 vs. 242 +/- 40). Pancreatic glucagon was initially similar after FB and WB, but a significant rise was observed with FB at 180 min (116 +/- 17 pg/ml vs. 67 +/- 18 P less than 0.05). The improvement of the blood glucose pattern with DF, especially the suppression of reactive hypoglycaemia, seems to depend partly on reduced and delayed response of the entero-hormonal axis. This in turn results in a better synergistic secretion of insulin and glucagon in the late post-prandial period.
尽管一些膳食纤维（DF）通过减缓碳水化合物吸收来改善葡萄糖耐量，但肯定还涉及其他机制。在6例葡萄糖耐量受损和反应性低血糖患者中研究了膳食纤维摄入后的一些肠激素反应。所有患者均接受两种不同的早餐，每种早餐均含有25 g以白面包（WB）或富含纤维的面包制品（FB）形式提供的淀粉：4 g半纤维素和4 g瓜尔胶。在5小时内评估代谢和激素反应。与白面包相比，富含纤维的面包制品对由此产生的血糖峰值（富含纤维的面包制品组为116±9 mg/100 ml，白面包组为148±15，P<0.025）或谷值（富含纤维的面包制品组为88±3 mg/100 ml，白面包组为79±5）以及60分钟时的胰岛素反应（富含纤维的面包制品组为20±4 μU/ml，白面包组为70±20）具有钝化作用。富含纤维的面包制品在90分钟（185±39对242±42，P<0.05）和150分钟（180±39对242±40）时肠道胰高血糖素免疫反应性降低。富含纤维的面包制品和白面包摄入后最初的胰高血糖素水平相似，但富含纤维的面包制品在180分钟时出现显著升高（116±17 pg/ml对67±18，P<0.05）。膳食纤维对血糖模式的改善，尤其是对反应性低血糖的抑制，似乎部分取决于肠激素轴反应的减弱和延迟。这反过来又导致餐后后期胰岛素和胰高血糖素更好的协同分泌。
