Kovalenko V N, Donchenko G V, Makovetskiĭ V P, Svishchuk A A
Ukr Biokhim Zh (1978). 1979 Nov-Dec;51(6):665-8.
When adding pharmacopoeian alpha-tocopherylacetate, short-chain alpha-tocopherylacetate, alpha-tocopherylquinine, short-chain alpha-tocopherylquinone and alpha-tocopheronolactone to E-avitaminotic rations pharmacopoeian alpha-tocopherylacetate and alpha-tocopheronolactone manifest the highest E-vitamin activity in preventing encephalomalacia in chickens. The action of alpha-tocopheronolactone is not directly associated with changes in the content of vitamin E and ubiquinone in the brain and liver tissues. All the studied derivatives are effective in increasing resistance of erythrocytes to osmotic hemolysis. The data obtained evidence for a nonspecific function of vitamin E in preventing alimentary encephalomalacia in chickens as well as for the absence of disturbances in ubiquinone metabolism under conditions of the E-hypovitaminosis experimental model.
在雏鸡维生素E缺乏日粮中添加药典规定的α-生育酚乙酸酯、短链α-生育酚乙酸酯、α-生育酚醌、短链α-生育酚醌和α-生育酚内酯时，药典规定的α-生育酚乙酸酯和α-生育酚内酯在预防雏鸡脑软化方面表现出最高的维生素E活性。α-生育酚内酯的作用与脑和肝组织中维生素E及泛醌含量的变化无直接关联。所有研究的衍生物在增强红细胞对渗透性溶血的抵抗力方面均有效。所获数据证明维生素E在预防雏鸡营养性脑软化方面具有非特异性功能，以及在维生素E缺乏症实验模型条件下泛醌代谢未受干扰。
