Kovalenko V N, Donchenko G V, Kuz'menko I V, Gurina N M, Makovetskiĭ V P
Vopr Pitan. 1982 Mar-Apr(2):44-9.
The efficacy of pharmacopeial alpha-tocopheryl acetate, alpha-tocopheronolactone and the antioxidant diludin was studied as to the possibilities of preventing E-hypovitaminosis muscle dystrophy in rabbits. alpha-Tocopheronolactone action was similar to that of pharmacopeial alpha-tocopheryl acetate as regards E-vitamin activity that was manifested by an increase in the body mass, decrease in the urine creatine index and maintenance of normal ubiquinone content, as well as of succinate-ubiquinone-reductase, NADH-ubiquinone-reductase and NADH-cytochrome c-reductase activity of rabbit skeletal muscle and heart mitochondria. On the contrary , as a result of the antioxidant administration, no direct correlation was found between ubiquinone content and activity of ubiquinone-dependent enzymatic systems of mitochondria. The data obtained attest to high E-vitamin activity of alpha-tocopheronolactone. The action of the latter was disclosed to be different from that produced by the antioxidant.
研究了药典规定的醋酸α-生育酚、α-生育酚内酯和抗氧化剂乙氧喹对预防家兔E型维生素缺乏性肌营养不良的可能性。就E型维生素活性而言，α-生育酚内酯的作用与药典规定的醋酸α-生育酚相似，表现为体重增加、尿肌酸指数降低、维持正常泛醌含量，以及家兔骨骼肌和心脏线粒体的琥珀酸-泛醌还原酶、NADH-泛醌还原酶和NADH-细胞色素c还原酶活性。相反，由于给予抗氧化剂，未发现泛醌含量与线粒体泛醌依赖性酶系统活性之间存在直接相关性。所获得的数据证明α-生育酚内酯具有高E型维生素活性。结果表明，后者的作用与抗氧化剂产生的作用不同。
