Reik L, Petzold G L, Higgins J A, Greengard P, Barrnett R J
Science. 1970 Apr 17;168(3929):382-4. doi: 10.1126/science.168.3929.382.
An electron microscopic procedure has been developed, using rat liver, for the localization of hormone-sensitive adenyl cyclase. Isoproterenol-sensitive adenyl cyclase is located almost exclusively in the parenchymal cells. In contrast, glucagon-sensitive adenyl cyclase is located primarily in the reticulo-endothelial cells but is also present in parenchymal cells. Sodium fluoride-sensitive adenyl cyclase is found in both cell types.
已开发出一种利用大鼠肝脏进行激素敏感性腺苷酸环化酶定位的电子显微镜方法。对异丙肾上腺素敏感的腺苷酸环化酶几乎仅存在于实质细胞中。相比之下，对胰高血糖素敏感的腺苷酸环化酶主要存在于网状内皮细胞中，但也存在于实质细胞中。在这两种细胞类型中均发现了对氟化钠敏感的腺苷酸环化酶。
