Voigt W H, Metzger K G
Arzneimittelforschung. 1979;29(12a):1937-9.
To examine the effect of 6-[(R)-2-(2-oxo-imidazolidine-1-carboxamido)-2-phenyl-acetamido]-penicillanic acid sodium salt (azlocillin, Securopen) on the ultrastructure of Pseudomonas aeruginosa investigations were carried out by electron microscopy on thin sections and on negative-stained preparations. Depending on the concentration and the contact time of azlocillin the bacteria showed distinct alterations. The bacterial cells did not build septa and therefore only grew in length up to 100-fold that of untreated controls. The bacteria diameter remained unchanged. Survival curves showed that these bacterial filaments were unable to build colonies. They were irreversibly damaged.
为研究6-[(R)-2-(2-氧代-咪唑烷-1-甲酰胺基)-2-苯基-乙酰胺基]-青霉烷酸钠盐（阿洛西林，苯咪唑青霉素）对铜绿假单胞菌超微结构的影响，通过电子显微镜对薄切片和负染色制剂进行了研究。根据阿洛西林的浓度和接触时间，细菌呈现出明显的变化。细菌细胞不形成隔膜，因此仅在长度上生长，可达未处理对照的100倍。细菌直径保持不变。存活曲线表明，这些细菌丝无法形成菌落。它们受到了不可逆的损伤。
