高血压利尿治疗期间的保钾药物。
Potassium-sparing agents during diuretic therapy in hypertension.
作者信息
McKenna T J, Donohoe J F, Brien T G, Healy J J, Canning B S, Muldowney F P
出版信息
Br Med J. 1971 Jun 26;2(5764):739-41. doi: 10.1136/bmj.2.5764.739.
Abstract
Three pharmacological agents in use as "potassium-sparing" drugs have been tested by serial measurements of total exchangeable potassium (K(E)) during 4 to 12 weeks of oral diuretic therapy in hypertensive subjects. Triamterene seemed ineffective in the dosage used (50 mg twice daily). Spironolactone (25 mg twice daily) reduced K loss to a considerable extent, while Slow-K (32 mEq daily) completely reversed previous K(E) deficits. Plasma K levels were a poor indication of degree of K(E) restoration.
摘要
在高血压患者口服利尿剂治疗4至12周期间，通过连续测量总可交换钾（K(E)），对三种用作“保钾”药物的药理剂进行了测试。氨苯蝶啶在所使用的剂量（每日两次，每次50毫克）下似乎无效。螺内酯（每日两次，每次25毫克）在很大程度上减少了钾的流失，而缓释钾（每日32毫当量）则完全逆转了先前的K(E)缺乏。血浆钾水平并不能很好地指示K(E)恢复的程度。
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