Gulati P D, Aurora A L, Mathur G P, Vaishnava H
Postgrad Med J. 1970 Mar;46(533):137-41. doi: 10.1136/pgmj.46.533.137.
The records of fifty-five patients with secondary renal amyloidosis have been scrutinized in order to evaluate statistically the correlation of the various clinical features and biochemical alterations with the severity of histological lesions in this disease. An ‘amyloid factor’, calculated on the basis of the extent of glomerular amyloid deposition, was utilized for the grading of the latter. A significant correlation of the histological grading was observed with the duration of predisposing illness ( <0·02), alteration of total serum protein ( <0·001) and functional impairment as determined by the creatinine clearance test ( <0·002). There was, however, no significant correlation between the extent of glomerular lesions and clinical severity, the duration of oedema, the degree of proteinuria and the levels of blood urea, serum albumin and serum cholesterol.
为了从统计学角度评估继发性肾淀粉样变性病的各种临床特征和生化改变与该病组织学病变严重程度之间的相关性，对55例患者的记录进行了详细审查。根据肾小球淀粉样沉积程度计算出的“淀粉样因子”用于对后者进行分级。观察到组织学分级与诱发疾病的持续时间（<0.02）、血清总蛋白改变（<0.001）以及通过肌酐清除率试验确定的功能损害（<0.002）之间存在显著相关性。然而，肾小球病变程度与临床严重程度、水肿持续时间、蛋白尿程度以及血尿素、血清白蛋白和血清胆固醇水平之间没有显著相关性。
