Suero J T, Woolf C R
J Clin Invest. 1970 Apr;49(4):747-51. doi: 10.1172/JCI106287.
The mechanical properties of the lungs in seven patients with chronic obstructive pulmonary disease (COPD) were measured before and during dyspnea on exertion, as well as when relief with added oxygen was obtained. Mean pulmonary dynamic compliance was 0.091 liters/cm of H(2)O before dyspnea, 0.057 during dyspnea, and 0.101 liters/cm H(2)O during relief. During dyspnea there was an increase in the total respiratory work (both elastic and nonelastic work) and this fell during relief with oxygen. Nonelastic resistance and respiratory rate were not significantly different during the three periods. In five similar patients a progressive increase in the instantaneous rate of change of transpulmonary pressure (dP/dt) was observed during exercise and this was markedly increased during dyspnea. These changes in dP/dt during exercise could explain the observed fall of pulmonary dynamic compliance.
在7例慢性阻塞性肺疾病（COPD）患者中，分别在运动性呼吸困难发作前、发作期间以及吸氧缓解时测量了肺的力学特性。呼吸困难发作前平均肺动态顺应性为0.091升/厘米水柱，发作期间为0.057，吸氧缓解时为0.101升/厘米水柱。呼吸困难发作期间总呼吸功（弹性和非弹性功）增加，吸氧缓解时则下降。三个时期的非弹性阻力和呼吸频率无显著差异。在5例类似患者中，运动期间观察到跨肺压瞬时变化率（dP/dt）逐渐增加，呼吸困难时显著升高。运动期间dP/dt的这些变化可以解释观察到的肺动态顺应性下降。
