Weaver R N, Gray J E, Schultz J R
Lab Anim Sci. 1975 Dec;25(6):705-10.
By means of polyacrylamide concentration and electrophoresis on cellulose acetate strips, protein fractions have been determined in the urine of male Sprague-Dawley rats from 6 1/2-28 mo of age. An increasing percentage of albumin was expressed in the albumin/globulin ratios of 0.72, in a group of rats excreting a mean concentration of 1.91 mg/ml of protein in the urine, and 2.24 in a group of rats excreting, on the average, 17.62 mg/ml. A relative decrease in globulin, particularly of the alpha2 fraction, was shown. From a statistical model based on the regression parameters for 24-hr protein excretion and urine protein concentration, it was estimated that the doubling time for protein excretion was 3.2-3.69 mo. This interval is roughly one-half that reported for the Wistar rat.
通过聚丙烯酰胺浓缩以及在醋酸纤维素条上进行电泳，测定了6.5至28月龄雄性斯普拉格-道利大鼠尿液中的蛋白质组分。在一组平均尿蛋白浓度为1.91毫克/毫升的大鼠中，白蛋白/球蛋白比值为0.72，白蛋白所占百分比不断增加；而在另一组平均尿蛋白浓度为17.62毫克/毫升的大鼠中，该比值为2.24。结果显示球蛋白相对减少，尤其是α2组分。基于24小时蛋白质排泄量和尿蛋白浓度的回归参数建立的统计模型估计，蛋白质排泄量的加倍时间为3.2至3.69个月。该时间间隔约为报道的威斯塔大鼠的一半。
