哺乳动物肝脏的核膜。II. 脂质组成。
Nuclear membranes from mammalian liver. II. Lipid composition.
作者信息
Kleinig H
出版信息
J Cell Biol. 1970 Aug;46(2):396-402. doi: 10.1083/jcb.46.2.396.
Abstract
The qualitative and quantitative lipid composition of nuclei and nuclear membranes from pig and rat liver were determined. These determinations were compared with the corresponding data obtained for microsomes from the same material after similar treatments. The results indicate that, at least, by far the major part of the nuclear lipids is located in the membranes of the nuclear envelope. The phospholipid pattern of the nuclear membranes and the endoplasmic reticulum (ER) membranes in general is widely identical in both species. As a striking difference in the lipid composition, however, a fourfold increase of esterified cholesterol in the nuclear membranes was found. In a quantitative approach the ratio of total surface area of the nuclear lipids to the total surface area of the nuclear envelope membranes was calculated as being 3.6, a value which fairly approximates the requirements of a bimolecular lipid leaflet model.
摘要
测定了猪和大鼠肝脏细胞核及核膜的定性和定量脂质组成。将这些测定结果与对相同材料经类似处理后得到的微粒体的相应数据进行了比较。结果表明，至少到目前为止，细胞核脂质的主要部分位于核膜。两种物种的核膜和内质网（ER）膜的磷脂模式总体上广泛相同。然而，作为脂质组成的一个显著差异，发现核膜中酯化胆固醇增加了四倍。在定量分析中，计算出核脂质的总表面积与核膜总表面积的比值为3.6，该值相当接近双分子脂质小叶模型的要求。
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本文引用的文献
1
The colorimetric micro-determination of long-chain fatty acids.长链脂肪酸的比色微量测定法。
Biochem J. 1963 Jul;88(1):7-10. doi: 10.1042/bj0880007.
2
Separation of the phosphoric esters on the filter paper chromatogram.磷酸酯在滤纸色谱上的分离
Nature. 1949 Dec 31;164(4183):1107-12, illust. doi: 10.1038/1641107a0.
3
QUANTITATIVE TWO-DIMENSIONAL THIN-LAYER CHROMATOGRAPHY OF NATURALLY OCCURRING PHOSPHOLIPIDS.天然存在的磷脂的定量二维薄层色谱法。
J Lipid Res. 1964 Oct;5:628-31.
4
SALINE-SOLUBLE PREPARATIONS OF DEOXYRIBONUCLEOPROTEINS.脱氧核糖核蛋白的盐溶性制剂
Arch Biochem Biophys. 1964 Jul 20;106:505-15. doi: 10.1016/0003-9861(64)90222-x.
5
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Biochim Biophys Acta. 1964 Jul 15;90:126-45. doi: 10.1016/0304-4165(64)90125-4.
6
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J Biol Chem. 1964 May;239:1335-45.
7
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8
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10
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Biochem J. 1960 Apr;75(1):45-53. doi: 10.1042/bj0750045.
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