Silverstone H, Searle J H
Br J Cancer. 1970 Jun;24(2):235-52. doi: 10.1038/bjc.1970.27.
On the basis of data gathered from long term residents of 3 widely separated regions of Queensland a multivariate analysis has been made to determine the influence of a number of factors in the aetiology of skin cancer and solar keratosis. Factors considered were age, sex, susceptibility to sunburn, complexion, eye colour, ancestry, occupation, clothing habits and residential district. For both sexes, both diseases and all age groups the factor "susceptibility to sunburn" proved to be the most powerful single discriminant. On the whole it appeared that the genetically based factors as a group provided more information on susceptibility than the environmental factors. The relative importance of "occupation" remains in some doubt. In the tropical area away from the coast it appears to be of considerable importance. In coastal areas its influence appears to be blunted, presumably by factors such as sports and recreation habits.
基于从昆士兰三个相距甚远地区的长期居民收集的数据，进行了多变量分析，以确定多种因素在皮肤癌和日光性角化病病因学中的影响。所考虑的因素包括年龄、性别、晒伤易感性、肤色、眼睛颜色、血统、职业、着装习惯和居住地区。对于男女两性、两种疾病以及所有年龄组，“晒伤易感性”这一因素被证明是最有力的单一判别因素。总体而言，似乎基于遗传的因素作为一个整体，比环境因素提供了更多关于易感性的信息。“职业”的相对重要性仍存在一些疑问。在远离海岸的热带地区，它似乎相当重要。在沿海地区，其影响似乎被削弱了，大概是受到体育和娱乐习惯等因素的影响。
