Setlow R B
Proc Natl Acad Sci U S A. 1974 Sep;71(9):3363-6. doi: 10.1073/pnas.71.9.3363.
DNA is taken as the target for skin cancer induced by ultraviolet light, and the known data on the sensitivity of DNA as a function of wavelength are summarized. The sun's spectrum at the surface of the earth and the DNA action spectrum are used to calculate the carcinogenic effectiveness as a function of wavelength. The most effective wavelengths at 30 degrees N latitude are <305 nm, and a 1% change in atmospheric ozone results in a 2% change in the effective dose of ultraviolet light. Since both the basic biological and physical data are reasonably precise, the major requirement for a quantitative evaluation of the dose response relation for ultraviolet-induced skin cancer in man is better epidemiological data to compare with data from animal models.
DNA被视为紫外线诱导皮肤癌的靶点，并总结了DNA敏感性随波长变化的已知数据。利用地球表面的太阳光谱和DNA作用光谱来计算致癌效果随波长的变化。北纬30度处最有效的波长小于305纳米，大气臭氧1%的变化会导致紫外线有效剂量2%的变化。由于基本的生物学和物理学数据都相当精确，对人类紫外线诱导皮肤癌剂量反应关系进行定量评估的主要要求是要有更好的流行病学数据，以便与动物模型的数据进行比较。
