Küchle H J, Richard G
Ophthalmologica. 1979;179(5):291-6. doi: 10.1159/000308909.
The authors report on 136 cases of arterial occlusion (80 patients suffering from occlusion of the retinal vessels and 56 patients with vascular occlusion in the optic nerve) who were treated with the vasoactive xanthic substance Pentoxifylline (Trental). A part from its positive effect on the vascular circulation, Trental also helps to improve microcirculation in the retinal and optic nerve tissue damaged by hypoxia. After a 2-week infusion therapy with additional digitalisation, treatment was continued for another 3-6 months with oral administration of Trental 400. In 50 cases therapy was combined with the systemic administration of corticosteroids. Under the mentioned therapy a definitely improved visual acuity (at least 3 lines on the eye charts) was achieved in 56% of the cases with occlusion of the retinal vessels and in 51% of the cases with vascular occlusion in the optic nerve, i.e., in 54% of the total number of patients. Whether or not the additional administration of corticosteroids helped to this effect was not proved.
作者报告了136例动脉闭塞患者（80例视网膜血管闭塞患者和56例视神经血管闭塞患者），这些患者接受了血管活性黄嘌呤类物质己酮可可碱（曲克芦丁）治疗。除了对血管循环有积极作用外，曲克芦丁还有助于改善因缺氧而受损的视网膜和视神经组织的微循环。在进行为期2周的输注治疗并额外进行洋地黄化后，继续口服400毫克曲克芦丁治疗3至6个月。50例患者的治疗联合了全身应用皮质类固醇。在上述治疗下，56%的视网膜血管闭塞患者和51%的视神经血管闭塞患者，即54%的患者总数，视力得到了明显改善（至少在视力表上提高3行）。皮质类固醇的额外应用是否有助于达到这一效果尚未得到证实。
