Intestinal hydrolysis and conjugation of a pesticidal carbamate in vitro.

The metabolite 1-[1-(14)C]naphthyl glucuronide was isolated from mucosal and serosal fluids of everted sacs of rat small intestine incubated in media containing either the insecticide 1-[1-(14)C]naphthyl N-methylcarbamate (carbaryl) or 1-[1-(14)C]naphthol. The hydrolysis of carbaryl and conjugation of the liberated naphthol indicated some degree of metabolism by the intestine before absorption.