南非印度人中的人类白细胞抗原与癌症

HLA and cancer in South African Indians.

作者信息

Hammond M G, Appadoo B, Brain P

出版信息

Tissue Antigens. 1979 Oct;14(4):296-302. doi: 10.1111/j.1399-0039.1979.tb00852.x.

DOI:10.1111/j.1399-0039.1979.tb00852.x

Abstract

Two-hundred-and-forty-nine Indian cancer patients were tested for 39 HLA antigens and the antigen frequencies were compared with those of 603 control subjects. Comparisons were also made between cancer patients and controls for each ethnic group and for each site of cancer. There was an increase in the frequency of the HLA antigens A11 and Bw52 in patients with malignancies. Heterozygosity at the B locus was significantly increased in patients with cancer of the breast. The Aw24, B17 haplotype was also associated with breast cancer.

摘要

对249名印度癌症患者进行了39种HLA抗原检测，并将抗原频率与603名对照受试者的频率进行了比较。还对每个种族群体和每个癌症部位的癌症患者与对照进行了比较。恶性肿瘤患者中HLA抗原A11和Bw52的频率有所增加。乳腺癌患者B位点的杂合性显著增加。Aw24、B17单倍型也与乳腺癌有关。