Pap A, Sarles H
Acta Med Acad Sci Hung. 1979;36(2):187-96.
The effect of intragastric and intraduodenal xylocaine on the pancreatic secretion was investigated in conscious rats. A 1% xylocaine infusion strongly decreased pancreatic protein output and flow during recirculation of pancreatic juice into the duodenum, but it diminished only moderately the increase in the secretion seen after its diversion and after duodenal infusion of soybean trypsin inhibitor. Moderate inhibition appeared during prolonged diversion of pancreatic juice. The response to exogenous CCK + secretin was not modified. The results indicate that during recirculation of pancreatic juice, which is more physiologic than its diversion from the duodenum, the neural control may play a significant role.
在清醒大鼠中研究了胃内和十二指肠内注入利多卡因对胰腺分泌的影响。在胰液回流入十二指肠的过程中，注入1%利多卡因可显著降低胰腺蛋白质输出量和胰液流量，但在胰液转流后以及十二指肠注入大豆胰蛋白酶抑制剂后，利多卡因仅适度减少了观察到的分泌增加。在胰液长期转流期间出现了中度抑制。对外源性胆囊收缩素 + 促胰液素的反应未发生改变。结果表明，在胰液回流入十二指肠（这比胰液从十二指肠转流更接近生理状态）的过程中，神经控制可能发挥重要作用。
