十二指肠内注射乙醇对胰腺外分泌作用的胆碱能机制。

Cholinergic mechanisms involved in the effect of intraduodenal ethanol on exocrine pancreatic secretion.

作者信息

Alonso R, Alvarez C, García L J, Calvo J J, López M A

机构信息

Departamento de Fisiología y Farmacología, Universidad de Salamanca, Spain.

出版信息

Z Gastroenterol. 1992 Feb;30(2):117-20.

PMID:1553824

Abstract

The effect of intraduodenal ethanol on exocrine pancreas of the rat in basal conditions has been studied. The pancreatic flow rate significantly increased to a maximum of 148% of basal after intraduodenal ethanol whereas only slight increases of protein output were observed. Ethanol perfusion in previously atropinized animals also elicited a significant increase of the flow rate up to a maximum of 177% of basal values but this increase appeared later than that observed in non-atropinized animals. Our results show that the ethanol action is successively stimulant followed by a simultaneously dual and antagonic effect (stimulant and inhibitory). Furthermore, this ethanol effect is mediated by cholinergic mechanisms. Finally, no effect of ethanol on portal plasma secretin and VIP levels was observed in atropinized or non-atropinized animals.

摘要

研究了基础条件下十二指肠内注入乙醇对大鼠外分泌胰腺的影响。十二指肠内注入乙醇后，胰腺流速显著增加，最高达到基础值的148%，而蛋白质输出仅略有增加。在先前已用阿托品处理的动物中进行乙醇灌注，也引起流速显著增加，最高达到基础值的177%，但这种增加比未用阿托品处理的动物出现得晚。我们的结果表明，乙醇的作用先是刺激作用，随后是同时具有双重和拮抗性质的作用（刺激和抑制）。此外，这种乙醇效应是由胆碱能机制介导的。最后，在已用阿托品处理或未用阿托品处理的动物中，均未观察到乙醇对门静脉血浆中促胰液素和血管活性肠肽水平的影响。