Suppr超能文献

骨髓细胞对离体灌注脾脏初次免疫反应的增强作用。

The enhancing effect of bone marrow cells on the primary immune response of the isolated perfused spleen.

作者信息

Atkins R C, Robinson W A, Eiseman B

出版信息

J Exp Med. 1970 Apr 1;131(4):833-42. doi: 10.1084/jem.131.4.833.

DOI:10.1084/jem.131.4.833
PMID:5464381
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2138782/
Abstract

The addition of bone marrow cells or peripheral lymphocytes to the isolated pig spleen markedly enhanced the primary antibody response after 3-day perfusion and antigenic challenge in vitro. The splenic preparation without added cells or with the addition of marrow cells to an irradiated spleen gave a limited response. Contributory evidence is provided that at least two distinct cell types are needed for antibody production. For optimal antibody response by an isolated perfused spleen, marrow cells or peripheral lymphocytes should be added to the system.

摘要

在体外进行3天灌注和抗原刺激后，向分离出的猪脾脏中添加骨髓细胞或外周淋巴细胞，可显著增强初次抗体反应。未添加细胞的脾脏制剂或向受辐照脾脏中添加骨髓细胞的制剂产生的反应有限。有证据表明，抗体产生至少需要两种不同的细胞类型。为使分离的灌注脾脏产生最佳抗体反应，应向系统中添加骨髓细胞或外周淋巴细胞。

相似文献

1
The enhancing effect of bone marrow cells on the primary immune response of the isolated perfused spleen.骨髓细胞对离体灌注脾脏初次免疫反应的增强作用。
J Exp Med. 1970 Apr 1;131(4):833-42. doi: 10.1084/jem.131.4.833.
2
A third non-adherent cell required for the in vitro immune response to sheep erythrocytes.对绵羊红细胞进行体外免疫反应所需的第三种非黏附细胞。
J Immunol. 1973 Aug;111(2):641-3.
3
Splenic replenishment of synergistic ability to bone marrow and thymic cells of neonatally splenectomized CBA mice.新生期脾切除的CBA小鼠脾脏对骨髓和胸腺细胞协同能力的补充作用。
J Exp Med. 1972 Oct 1;136(4):761-8. doi: 10.1084/jem.136.4.761.
4
Sedimentation analysis of the cells in mice required to initiate an in vivo immune response to sheep erythrocytes.
Proc Soc Exp Biol Med. 1970 Oct;135(1):63-7. doi: 10.3181/00379727-135-34988.
5
Antibody formation by bone marrow cells in irradiated mice. I. Thymus-dependent and thymus-independent responses to sheep erythrocytes.受照射小鼠骨髓细胞的抗体形成。I. 对绵羊红细胞的胸腺依赖性和非胸腺依赖性反应。
Immunology. 1971 Jul;21(1):113-21.
6
Cells involved in the immune response. XIV. The immunologic response of irradiated rabbits given allogeneic bone marrow cells incubated with antigen and-or subjected to irradiation in vitro.参与免疫反应的细胞。十四、经体外与抗原孵育和/或照射的同种异体骨髓细胞对受照射兔的免疫反应。
J Immunol. 1970 Apr;104(4):1009-15.
7
Cells involved in the immune response. XXIV. The demonstration of the multiclonal nature of the antigen-reactive cell population in the bone marrow of the normal adult rabbit.参与免疫反应的细胞。二十四。正常成年兔骨髓中抗原反应性细胞群体多克隆性质的证明。
J Immunol. 1971 Sep;107(3):903-5.
8
The immune response of mice treated with anti-mu antibodies: the effect on antibody-forming cells, their precursors and helper cells assayed in vitro.用抗μ抗体处理的小鼠的免疫反应：对体外测定的抗体形成细胞、其前体和辅助细胞的影响。
J Immunol. 1975 Jun;114(6):1808-12.
9
Cells involved in the immune response. 18. Potential hemolysin-forming cells in the sacculus rotundus of the normal adult rabbit.参与免疫反应的细胞。18. 正常成年兔圆小囊中的潜在溶血素形成细胞。
J Immunol. 1970 May;104(5):1087-93.
10
Identification of the cell population responding to DNP-GL in lethally irradiated strain 13 chimeric guinea pigs reconstituted with strain 13 bone marrow and (2 x 13) F 1 lymph node and spleen cells.在接受致死剂量照射并用13号品系骨髓以及（2×13）F1淋巴结和脾细胞重建的13号品系嵌合豚鼠中，鉴定对二硝基苯基-球蛋白（DNP-GL）有反应的细胞群体。
Cell Immunol. 1970 Oct;1(4):445-54. doi: 10.1016/0008-8749(70)90020-1.

引用本文的文献

1
Changes in the synthesis of antibiodies and non-specific immunoglobulins in the spleen perfused in vitro.体外灌注脾脏中抗体和非特异性免疫球蛋白合成的变化。
Immunology. 1971 Dec;21(6):915-24.
2
Time-dependent synergism of rats spleen and bone marrow cells.大鼠脾脏和骨髓细胞的时间依赖性协同作用。
Immunology. 1972 May;22(5):901-5.

本文引用的文献

1
Reactivation in vitro of immunocompetence in irradiated mouse spleen.照射鼠脾免疫活性的体外再激活。
J Exp Med. 1967 Aug 1;126(2):223-34. doi: 10.1084/jem.126.2.223.
2
Plaque Formation in Agar by Single Antibody-Producing Cells.琼脂中由单个抗体产生细胞形成的斑块。
Science. 1963 Apr 26;140(3565):405. doi: 10.1126/science.140.3565.405.
3
A THREE-CELL INTERACTION REQUIRED FOR THE INDUCTION OF THE PRIMARY IMMUNE RESPONSE in vitro.体外诱导初次免疫反应所需的三细胞相互作用。
Proc Natl Acad Sci U S A. 1968 Oct;61(2):542-7. doi: 10.1073/pnas.61.2.542.
4
SEPARATION OF VIABLE LYMPHOCYTES FROM HUMAN BLOOD.从人血中分离活淋巴细胞
Lancet. 1964 Feb 29;1(7331):468-9. doi: 10.1016/s0140-6736(64)90799-8.
5
Quantitative studies of the adoptive immunological memory in mice. II. Linear transmission of cellular memory.小鼠过继免疫记忆的定量研究。II. 细胞记忆的线性传递。
J Exp Med. 1967 Feb 1;125(2):199-211. doi: 10.1084/jem.125.2.199.
6
Thymus-marrow cell combinations. Synergism in antibody production.胸腺-骨髓细胞组合。抗体产生中的协同作用。
Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1167-71. doi: 10.3181/00379727-122-31353.
7
Immunization of normal mouse spleen cell suspensions in vitro.体外对正常小鼠脾细胞悬液进行免疫接种。
Science. 1966 Aug 26;153(3739):1004-6. doi: 10.1126/science.153.3739.1004.
8
Primary immune reactions in organ cultures.器官培养中的初次免疫反应。
Science. 1965 Aug 27;149(3687):991-3. doi: 10.1126/science.149.3687.991.
9
The enhancing effect of bone marrow cells on the immune response of irradiated mice reconstituted with spleen cells from normal and immunized donors.骨髓细胞对用来自正常和免疫供体的脾细胞重建的受辐照小鼠免疫反应的增强作用。
J Immunol. 1968 Apr;100(4):756-9.
10
Synthesis of antibody by spleen cells after exposure to kiloroentgen doses of ionizing radiation.暴露于千伦琴剂量的电离辐射后脾细胞抗体的合成。
J Cell Physiol. 1967 Jun;69(3):355-66. doi: 10.1002/jcp.1040690312.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验