Cathcart E S, Idelson B A, Scheinberg M A, Couser W G
Lancet. 1976 Jan 24;1(7952):163-6. doi: 10.1016/s0140-6736(76)91272-1.
Seven patients with diffuse proliferative lupus nephritis were subjected to highdose intravenous methylprednisolone (pulse) therapy. Following the pulse, five patients with rapidly deteriorating ranal function improved within three days and their serum-creatinine levels returned to baseline by one month. All seven patients demonstrated reversal of severe immunological abnormalities including increased serum D.N.A binding, decreased serum C3 levels, and reduced number of T lymphocytes in the peripheral blood. This form of therapy may make it possible to maintain patients with lupus nephritis on lower doses of steroids than is normally feasible.
七名弥漫性增殖性狼疮性肾炎患者接受了大剂量静脉注射甲基强的松龙（冲击）治疗。冲击治疗后，五名肾功能迅速恶化的患者在三天内病情改善，血清肌酐水平在一个月内恢复至基线。所有七名患者均显示严重免疫异常得到逆转，包括血清DNA结合增加、血清C3水平降低以及外周血T淋巴细胞数量减少。这种治疗方式可能使狼疮性肾炎患者能够维持使用比通常可行剂量更低的类固醇药物。
