Ibrahim A L, Zee Y C, Osebold J W
J Environ Pathol Toxicol. 1979 Dec;3(1-2):251-8.
Ultrastructural alterations in the tracheal and bronchial epithelium of mice exposed to 0.8 ppm ozone for varying periods of time were examined with scanning electron microscopy. The lesions were apparent in the ciliated cells. Examination of tissue from control mice showed that the ciliated cells were arranged in groups and the cilia were uniform in length. After six days of exposure to ozone, shortened cilia were occasionally observed by day 10, more pronounced changes were observed. Cilia were either absent or became short and blunt. The lesions observed after 20 days in ozone were similar to those seen on day 10. After ozone-exposed mice had been returned to ambient air for 10 days, ciliary regeneration occurred and, the major airways had a surface appearance approaching the normal state.
用扫描电子显微镜检查了暴露于0.8 ppm臭氧不同时间段的小鼠气管和支气管上皮的超微结构变化。病变在纤毛细胞中很明显。对对照小鼠组织的检查表明，纤毛细胞成组排列，纤毛长度均匀。暴露于臭氧6天后，到第10天偶尔观察到纤毛缩短，观察到更明显的变化。纤毛要么缺失，要么变短变钝。在臭氧中暴露20天后观察到的病变与第10天所见相似。臭氧暴露小鼠返回环境空气10天后，发生了纤毛再生，主要气道的表面外观接近正常状态。
