Berg K J
Eur J Clin Pharmacol. 1977 Jan 3;11(2):117-23. doi: 10.1007/BF00562902.
The acute effects of therapeutic doses of acetylsalicylic acid (ASA) on renal water and solute output, and the possible interaction of ASA with the diuretic effects of furosemide, have been studied in a double blind double cross over study in healthy human subjects. There was a significant decrease in 24 h sodium excretion and Na/K ratio in urine in the ASA-treated subjects. The effect of ASA on urinary sodium excretion was most prominent during day time (8 a.m.-10 p.m.) and on days with low sodium intake, as confirmed by control sodium excretion and plasma renin activity. A decrease in urine volume and an increase in tubular reabsorption of free water were caused by ASA, the antidiuretic effect being most marked at night (10 p.m.-8 a.m.). No action of ASA on the effect of furosemide on urinary sodium excretion was found. Creatinine clearance remained unaltered by ASA treatment, and ASA did not interfere with the increase in urinary creatinine excretion after furosemide treatment.
在一项针对健康人类受试者的双盲双交叉研究中，研究了治疗剂量的乙酰水杨酸（ASA）对肾脏水和溶质排出的急性影响，以及ASA与呋塞米利尿作用之间可能的相互作用。接受ASA治疗的受试者24小时尿钠排泄量和尿中钠/钾比值显著降低。通过对照钠排泄和血浆肾素活性证实，ASA对尿钠排泄的影响在白天（上午8点至晚上10点）以及钠摄入量低的日子最为显著。ASA导致尿量减少和肾小管对自由水的重吸收增加，抗利尿作用在夜间（晚上10点至上午8点）最为明显。未发现ASA对呋塞米尿钠排泄作用有影响。ASA治疗后肌酐清除率未改变，且ASA不干扰呋塞米治疗后尿肌酐排泄的增加。
